达松霉素 A 和 B，一种来源于海洋海绵 SCSIO 40065 的多环硫代生物碱。

Dassonmycins A and B, Polycyclic Thioalkaloids from a Marine Sponge-Derived SCSIO 40065.

机构信息

Key Laboratory of Tropical Marine Bioresources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.

University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China.

出版信息

Org Lett. 2021 Apr 16;23(8):2858-2862. doi: 10.1021/acs.orglett.1c00328. Epub 2021 Mar 11.

DOI:10.1021/acs.orglett.1c00328

PMID:33703905

Abstract

Two polycyclic thioalkaloides dassonmycins A () and B () were isolated from SCSIO 40065 associated with marine sponge sp. Structures of and were elucidated by comprehensive spectroscopic analysis and confirmed by single-crystal X-ray diffraction experiments, to have a 6/6/6/6-fused tetracyclic ring featuring a naphthoquinone[2,3-]piperazine[1,2-]thiomorpholine scaffold. Compound formed a caged core through an additional ether bridge. Both compounds exhibited moderate antibacterial and cytotoxic activities.

摘要

从与海洋海绵相关的 SCSIO 40065 中分离得到两种多环硫代生物碱 dassonmycins A()和 B()。通过综合光谱分析阐明了和的结构，并通过单晶 X 射线衍射实验证实，具有 6/6/6/6-稠合的四环环，具有萘醌[2,3-]哌嗪[1,2-]硫代吗啉支架。化合物通过额外的醚桥形成笼状核心。这两种化合物均表现出中等的抗菌和细胞毒性活性。