High Magnetic Field Laboratory, Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science , Chinese Academy of Sciences , Hefei 230031 , People's Republic of China.
Institutes of Chronic Disease , Qingdao University , Qingdao 266003 , People's Republic of China.
J Nat Prod. 2019 May 24;82(5):1331-1337. doi: 10.1021/acs.jnatprod.9b00100. Epub 2019 Apr 17.
Six new nardosinane-type sesquiterpenoids, clavukoellians A-F (1-6), together with one new neolemnane-type sesquiterpene, 4- O-deacetylparalemnolin D (7), were isolated from the marine soft coral Clavularia koellikeri. The structures of compounds 1-7 were elucidated by NMR spectroscopy, ECD analysis, and quantum chemical calculation methods. Compounds 1 and 7 demonstrated significant antiangiogenic activities in wound healing assays on HUVECs.
从海洋软珊瑚 Clavularia koellikeri 中分离得到了 6 个新的纳多辛烷型倍半萜类化合物，克拉沃埃利安 A-F（1-6），以及一个新的新莱曼烷型倍半萜类化合物，4-O-去乙酰巴莱曼宁 D（7）。通过 NMR 光谱、ECD 分析和量子化学计算方法阐明了化合物 1-7 的结构。化合物 1 和 7 在 HUVECs 的创伤愈合试验中表现出显著的抗血管生成活性。
