Curvall M, Enzell C R
Arch Toxicol Suppl. 1986;9:88-102. doi: 10.1007/978-3-642-71248-7_10.
Recent studies indicate that nonsmokers exposed to environmental tobacco smoke (ETS) acquire an impaired lung function and run an increased risk of lung cancer. These findings have been questioned mainly on the basis that the amount of ETS received by the nonsmoker has remained unquantified. The factural risk of ETS exposure could possibly be estimated by measuring the absorption of tobacco smoke products by nonsmokers. Nicotine, which is specific to tobacco, and its main metabolite, cotinine, have been used for this purpose. The usefulness of these markers based on data obtained for different body fluids from nonsmokers exposed to ETS under experimental as well as field conditions is discussed.
近期研究表明，暴露于环境烟草烟雾（ETS）中的非吸烟者会出现肺功能受损，患肺癌的风险也会增加。这些发现主要受到质疑，因为非吸烟者接触到的环境烟草烟雾量尚未得到量化。通过测量非吸烟者对烟草烟雾产物的吸收情况，有可能估算出暴露于环境烟草烟雾的实际风险。尼古丁是烟草特有的物质，其主要代谢产物可替宁已被用于此目的。本文讨论了基于在实验和现场条件下从暴露于环境烟草烟雾的非吸烟者不同体液中获得的数据，这些标志物的实用性。
