Boukerb Amine Mohamed, Cambronel Melyssa, Rodrigues Sophie, Mesguida Ouiza, Knowlton Rikki, Feuilloley Marc G J, Zommiti Mohamed, Connil Nathalie
Laboratoire de Microbiologie Signaux et Microenvironnement EA 4312, Université de Rouen, Normandie Université, Évreux, France.
EA 3884, LBCM, IUEM, Université de Bretagne-Sud, Lorient, France.
Front Microbiol. 2021 Oct 6;12:690942. doi: 10.3389/fmicb.2021.690942. eCollection 2021.
Prokaryotes and eukaryotes have coexisted for millions of years. The hormonal communication between microorganisms and their hosts, dubbed inter-kingdom signaling, is a recent field of research. Eukaryotic signals such as hormones, neurotransmitters or immune system molecules have been shown to modulate bacterial physiology. Among them, catecholamines hormones epinephrine/norepinephrine, released during stress and physical effort, or used therapeutically as inotropes have been described to affect bacterial behaviors (i.e., motility, biofilm formation, virulence) of various Gram-negative bacteria (e.g., serovar Typhimurium, sp.). More recently, these molecules were also shown to influence the physiology of some Gram-positive bacteria like In and , the stress-associated mammalian hormones epinephrine and norepinephrine trigger a signaling cascade by interacting with the QseC histidine sensor kinase protein. No catecholamine sensors have been well described yet in other bacteria. This review aims to provide an up to date report on catecholamine sensors in eukaryotes and prokaryotes, their transport, and known effects on bacteria.
原核生物和真核生物已经共存了数百万年。微生物与其宿主之间的激素通讯，即所谓的跨王国信号传导，是一个新的研究领域。诸如激素、神经递质或免疫系统分子等真核信号已被证明可调节细菌生理。其中，在应激和体力活动期间释放或作为强心剂用于治疗的儿茶酚胺类激素肾上腺素/去甲肾上腺素已被描述会影响各种革兰氏阴性菌（如鼠伤寒血清型、种）的细菌行为（即运动性、生物膜形成、毒力）。最近，这些分子还被证明会影响一些革兰氏阳性菌的生理，如在和中，与应激相关的哺乳动物激素肾上腺素和去甲肾上腺素通过与QseC组氨酸传感器激酶蛋白相互作用触发信号级联反应。其他细菌中尚未对儿茶酚胺传感器进行充分描述。本综述旨在提供关于真核生物和原核生物中儿茶酚胺传感器、它们的转运以及对细菌已知影响的最新报告。
