Guan Li-Jun, Song Ji-Jian, Xue Yun, Ai Xia, Liu Zhi-Jun, Si Li-Fang, Li Meng-Yun, Zhao Zhan-Qin
Laboratory of Veterinary Biologics Engineering, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China.
Key-Disciplines Lab of Safety of Environment and Animal Product, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China.
Vaccines (Basel). 2021 Oct 9;9(10):1155. doi: 10.3390/vaccines9101155.
Capsular type A and D strains of are the main epidemic serogroups in pigs in China. In this study, we preliminarily evaluated the immune protective efficacy of the two traditional vaccines, an inactivated C44-1 aluminum-hydroxide-gel-adjuvanted (Alh-C44-1) vaccine and a live EO630 vaccine, against currently circulating strains of in a mouse model. Mice immunized twice with conventional vaccines generated higher antibody titers, and significantly higher levels of IgG were observed in the mice inoculated with the inactivated Alh-C44-1 vaccine on day 35 ( < 0.05) than those with the live EO630 vaccine. The mice immune protection test showed that the vaccination groups had a 57% or 71% protection effect against the serogroup B strain, but had no protective effect against epidemic strains. In conclusion, our study found that the widely used traditional vaccines in China provide good protection against homologous strains, but could not provide cross-protection against heterologous strains in a mouse model.
A 型和 D 型荚膜菌株是中国猪群中的主要流行血清群。在本研究中，我们在小鼠模型中初步评估了两种传统疫苗（一种是灭活的 C44-1 氢氧化铝凝胶佐剂（Alh-C44-1）疫苗，另一种是活 EO630 疫苗）对当前流行菌株的免疫保护效果。用传统疫苗免疫两次的小鼠产生了更高的抗体滴度，在第 35 天，接种灭活 Alh-C44-1 疫苗的小鼠中观察到的 IgG 水平显著高于接种活 EO630 疫苗的小鼠（<0.05）。小鼠免疫保护试验表明，疫苗接种组对 B 血清群菌株有 57%或 71%的保护作用，但对流行菌株没有保护作用。总之，我们的研究发现，在中国广泛使用的传统疫苗对同源菌株具有良好的保护作用，但在小鼠模型中不能对异源菌株提供交叉保护。
