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一种新型研发的含有银/氧化锌（Ag/ZnO）纳米颗粒的生物活性复合树脂，作为针对……、……和……的抗菌材料。 （原文中“against”后面未完整列出具体对象）

A Novel Developed Bioactive Composite Resin Containing Silver/Zinc Oxide (Ag/ZnO) Nanoparticles as an Antimicrobial Material against , , and .

作者信息

Kachoei Mojgan, Divband Baharak, Rahbar Mahdi, Esmaeilzadeh Mahdiyeh, Ghanizadeh Milad, Alam Mostafa

机构信息

Department of Orthodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.

Dental and Periodontal Research Center, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.

出版信息

Evid Based Complement Alternat Med. 2021 Oct 16;2021:4743411. doi: 10.1155/2021/4743411. eCollection 2021.

DOI:10.1155/2021/4743411
PMID:34697547
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8541865/
Abstract

AIM

The objectives of this study were to develop a new bioactive composite resin containing silver/zinc oxide (Ag/ZnO) nanoparticles and investigate the effects on mechanical, cytotoxic, biocompatibility, and antimicrobial properties.

MATERIALS AND METHODS

Disc-shaped specimens were prepared from composite with and without nanoparticles in separate culture media containing , , and . Bracket bonding evaluation was performed on composite without nanoparticles (O), composite containing ZnO (Z) nanoparticles, composite containing ZnO nanoparticles and silver ions (A&Z), and composite containing Ag/ZnO nanoparticles (AZ) synthesized using optical precipitation.

RESULTS

Composite resin with nanoparticles (AZ, A&Z, and Z) showed significant antimicrobial properties ( < 0.05). The mean shear bond strength of A&Z composite resin (13.61 ± 0.73 MPa) was significantly less than that of conventional composite resin (19.03 ± 4.12 MPa) ( < 0.05). In addition, the mean shear bond strength of AZ composite resin (20.49 ± 1.03 MPa) was significantly higher than that of Z (16.35 ± 1.03 MPa) and A&Z composite resins.

CONCLUSIONS

Incorporation of ZnO nanoparticles and their compounds into orthodontic composite resins induced antibacterial properties against oral pathogens, and of all these nanoparticles, the AZ group exhibited the best antimicrobial activity and highest shear bond strength.

摘要

目的

本研究的目的是开发一种含银/氧化锌（Ag/ZnO）纳米颗粒的新型生物活性复合树脂，并研究其对机械性能、细胞毒性、生物相容性和抗菌性能的影响。

材料与方法

在分别含有、和的培养基中，用含纳米颗粒和不含纳米颗粒的复合材料制备圆盘形试样。对不含纳米颗粒的复合材料（O）、含氧化锌（Z）纳米颗粒的复合材料、含氧化锌纳米颗粒和银离子的复合材料（A&Z）以及采用光沉淀法合成的含Ag/ZnO纳米颗粒的复合材料（AZ）进行托槽粘结评估。

结果

含纳米颗粒的复合树脂（AZ、A&Z和Z）显示出显著的抗菌性能（<0.05）。A&Z复合树脂的平均剪切粘结强度（13.61±0.73MPa）显著低于传统复合树脂（19.03±4.12MPa）（<0.05）。此外，AZ复合树脂的平均剪切粘结强度（20.49±1.03MPa）显著高于Z（16.35±1.03MPa）和A&Z复合树脂。

结论

将氧化锌纳米颗粒及其化合物掺入正畸复合树脂中可诱导对口腔病原体的抗菌性能，在所有这些纳米颗粒中，AZ组表现出最佳的抗菌活性和最高的剪切粘结强度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba44/8541865/4ec4a503ba0e/ECAM2021-4743411.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba44/8541865/fcf6233a3cb8/ECAM2021-4743411.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba44/8541865/4f946a17eac0/ECAM2021-4743411.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba44/8541865/30ee2efacbce/ECAM2021-4743411.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba44/8541865/4ec4a503ba0e/ECAM2021-4743411.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba44/8541865/fcf6233a3cb8/ECAM2021-4743411.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba44/8541865/4f946a17eac0/ECAM2021-4743411.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba44/8541865/30ee2efacbce/ECAM2021-4743411.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba44/8541865/4ec4a503ba0e/ECAM2021-4743411.004.jpg

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