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涂有银或氧化锌纳米颗粒的正畸带环的细胞活力和抗菌效果评估：一项研究。

Evaluation of the cell viability and antimicrobial effects of orthodontic bands coated with silver or zinc oxide nanoparticles: An study.

作者信息

Bahrami Rashin, Pourhajibagher Maryam, Badiei Alireza, Masaeli Reza, Tanbakuchi Behrad

机构信息

Department of Orthodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.

Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Korean J Orthod. 2023 Jan 25;53(1):16-25. doi: 10.4041/kjod22.091.

DOI:10.4041/kjod22.091
PMID:36696956
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9877365/
Abstract

OBJECTIVE

We aimed to evaluate the cell viability and antimicrobial effects of orthodontic bands coated with silver or zinc oxide nanoparticles (nano-Ag and nano-ZnO, respectively).

METHODS

In this experimental study, 30 orthodontic bands were divided into three groups (n = 10 each): control (uncoated band), Ag (silver-coated band), and ZnO (zinc oxide-coated band). The electrostatic spray-assisted vapor deposition method was used to coat orthodontic bands with nano-Ag or nano-ZnO. The biofilm inhibition test was used to assess the antimicrobial effectiveness of nano-Ag and nano-ZnO against , , and . Biocompatibility tests were conducted using the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide assay. The groups were compared using oneway analysis of variance with a post-hoc test.

RESULTS

The Ag group showed a significantly higher reduction in the number of , , and colonies than the ZnO group ( = 0.015, 0.003, and 0.005, respectively). Compared with the control group, the Ag group showed a 2-log reduction in all the microorganisms' replication ability, but only showed a 2-log reduction in replication ability in the ZnO group. The lowest mean cell viability was observed in the Ag group, but the difference between the groups was insignificant ( > 0.05).

CONCLUSIONS

Coating orthodontic bands with nano-ZnO or nano-Ag induced antimicrobial effects against oral pathogens. Among the nanoparticles, nano-Ag showed the best antimicrobial activity and nano-ZnO showed the highest biocompatibility.

摘要

目的

我们旨在评估涂有银或氧化锌纳米颗粒（分别为纳米银和纳米氧化锌）的正畸带环的细胞活力和抗菌效果。

方法

在本实验研究中，30个正畸带环被分为三组（每组n = 10）：对照组（未涂层带环）、银组（涂银带环）和氧化锌组（涂氧化锌带环）。采用静电喷雾辅助气相沉积法用纳米银或纳米氧化锌涂覆正畸带环。生物膜抑制试验用于评估纳米银和纳米氧化锌对 、 和 的抗菌效果。使用3-(4,5-二甲基噻唑-2-基)-2,5-二苯基四氮唑溴盐试验进行生物相容性测试。采用单因素方差分析和事后检验对各组进行比较。

结果

银组的 、 和 菌落数量减少幅度显著高于氧化锌组（分别为 = 0.015、0.003和0.005）。与对照组相比，银组所有微生物的复制能力均降低了2个对数，但氧化锌组仅 显示复制能力降低了2个对数。银组的平均细胞活力最低，但各组之间的差异不显著（ > 0.05）。

结论

用纳米氧化锌或纳米银涂覆正畸带环可诱导对口腔病原体的抗菌效果。在纳米颗粒中，纳米银显示出最佳的抗菌活性，纳米氧化锌显示出最高的生物相容性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc6c/9877365/36d15fc37212/kjod-53-1-16-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc6c/9877365/201c512e5e37/kjod-53-1-16-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc6c/9877365/fda8a2edd68c/kjod-53-1-16-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc6c/9877365/9ec67cea65b4/kjod-53-1-16-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc6c/9877365/a426bcbe7d5c/kjod-53-1-16-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc6c/9877365/d11e4ae71292/kjod-53-1-16-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc6c/9877365/d0fdc1a8466f/kjod-53-1-16-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc6c/9877365/fddd0966e0f1/kjod-53-1-16-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc6c/9877365/36d15fc37212/kjod-53-1-16-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc6c/9877365/201c512e5e37/kjod-53-1-16-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc6c/9877365/fda8a2edd68c/kjod-53-1-16-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc6c/9877365/9ec67cea65b4/kjod-53-1-16-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc6c/9877365/a426bcbe7d5c/kjod-53-1-16-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc6c/9877365/d11e4ae71292/kjod-53-1-16-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc6c/9877365/d0fdc1a8466f/kjod-53-1-16-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc6c/9877365/fddd0966e0f1/kjod-53-1-16-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc6c/9877365/36d15fc37212/kjod-53-1-16-f8.jpg

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