Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Anesthesiology, Huashan Hospital, Fudan University, Shanghai, China.
Front Cell Infect Microbiol. 2021 Oct 14;11:760076. doi: 10.3389/fcimb.2021.760076. eCollection 2021.
In recent years, increasing studies have been conducted on the mechanism of gut microbiota in neuropsychiatric diseases and non-neuropsychiatric diseases. The academic community has also recognized the existence of the microbiota-gut-brain axis. Chronic pain has always been an urgent difficulty for human beings, which often causes anxiety, depression, and other mental symptoms, seriously affecting people's quality of life. Hyperalgesia is one of the main adverse reactions of chronic pain. The mechanism of gut microbiota in hyperalgesia has been extensively studied, providing a new target for pain treatment. Enterochromaffin cells, as the chief sentinel for sensing gut microbiota and its metabolites, can play an important role in the interaction between the gut microbiota and hyperalgesia through paracrine or neural pathways. Therefore, this systematic review describes the role of gut microbiota in the pathological mechanism of hyperalgesia, learns about the role of enterochromaffin cell receptors and secretions in hyperalgesia, and provides a new strategy for pain treatment by targeting enterochromaffin cells through restoring disturbed gut microbiota or supplementing probiotics.
近年来，越来越多的研究关注肠道微生物群在神经精神疾病和非神经精神疾病中的作用。学术界也认识到了微生物群-肠道-大脑轴的存在。慢性疼痛一直是人类的一个紧迫难题，它常常导致焦虑、抑郁等精神症状，严重影响人们的生活质量。痛觉过敏是慢性疼痛的主要不良反应之一。肠道微生物群在痛觉过敏中的作用机制已得到广泛研究，为疼痛治疗提供了新的靶点。肠嗜铬细胞作为感知肠道微生物群及其代谢物的主要哨兵细胞，通过旁分泌或神经途径，在肠道微生物群与痛觉过敏的相互作用中发挥重要作用。因此，本系统综述描述了肠道微生物群在痛觉过敏病理机制中的作用，了解了肠嗜铬细胞受体和分泌在痛觉过敏中的作用，并通过恢复紊乱的肠道微生物群或补充益生菌来靶向肠嗜铬细胞，为疼痛治疗提供了新的策略。
