Department of Community Mental Health and Law, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Japan.
Neuropsychopharmacol Rep. 2021 Dec;41(4):459-463. doi: 10.1002/npr2.12216. Epub 2021 Nov 1.
Outcome selection in intervention studies is a critical issue for synthesizing evidence. This study is aimed to investigate outcomes used in Cochrane reviews assessing community-based psychosocial interventions for adults with severe mental illness.
Cochrane reviews that evaluated a community-based psychosocial intervention for adults with severe mental illness were searched electronically and manually. We extracted all outcomes specified in the Methods section in each Cochrane review. Outcomes that represent the same concept and context were synthesized into an outcome term. Outcome terms were categorized according to the existing taxonomy.
We included 33 Cochrane reviews. Of the 216 outcome terms identified, 13 were used in more than half of the reviews: quality of life, mental state, admission to hospital, economic outcome, leaving the study early, social functioning, satisfaction, global state, relapse, adverse events/effects, carer satisfaction, employment, and duration of admission. Most outcome terms were categorized into the life impact core area (55%), followed by the resource use area (21%).
Our study provides a candidate outcome list for developing a core outcome set for severe mental illness and offers a basis for comparison for future outcome investigation on mental health research.
干预研究中的结局选择对于综合证据至关重要。本研究旨在调查评估针对严重精神疾病成年患者的社区心理社会干预的 Cochrane 综述中使用的结局。
电子检索和手工检索评估社区心理社会干预对严重精神疾病成年患者的 Cochrane 综述。我们从每项 Cochrane 综述的方法部分中提取所有指定的结局。代表相同概念和背景的结局被综合成一个结局术语。结局术语根据现有分类法进行分类。
我们纳入了 33 项 Cochrane 综述。在确定的 216 个结局术语中,有 13 个被超过一半的综述使用:生活质量、精神状态、住院、经济结局、提前退出研究、社会功能、满意度、总体状态、复发、不良事件/效应、照顾者满意度、就业和住院时间。大多数结局术语被归入生活影响核心领域(55%),其次是资源使用领域(21%)。
我们的研究为开发严重精神疾病的核心结局集提供了候选结局清单,并为未来心理健康研究的结局调查提供了比较基础。