Faculty of Medicine, University of Ss Cyril and Methodius, Institute of Preclinical and Clinical Pharmacology and Toxicology, Skopje, Republic of North Macedonia.
Intensive Care Unit, University Clinic for Infectious Diseases and Febrile Conditions, Skopje, Republic of North Macedonia.
Redox Rep. 2021 Dec;26(1):184-189. doi: 10.1080/13510002.2021.1999126.
COVID-19 is characterized by the presence of oxidative stress. Vitamin D status has been reviewed as one of the factors that may affect disease severity. The aim of this study was to assess the relationship between serum vitamin D levels, oxidative stress markers and disease severity in hospitalized COVID-19 patients.
Vitamin D levels were measured in 33 patients with COVID-19. The total antioxidant power and plasma peroxides were determined in serum.
Severe COVID-19 patients have lower vitamin D levels (18.39 ± 2.29 ng/mL vs. 28.47 ± 3.05 ng/mL, < .05) and higher oxidative stress compared to the moderate group. When divided according to serum vitamin D levels, significantly higher values of LDH (604.8 ± 76.98 IU/mL vs. 261.57 ± 47.33 IU/mL) and D-dimer (5978 ± 2028ng/mL vs. 977.7 ± 172 ng/mL) were obtained in the group with vitamin D below 30 ng/mL, followed with significantly higher levels of plasma peroxides (d-ROMs: 414.9 ± 15.82 U.Carr vs. 352.4 ± 18.77 U.Carr; < .05) and oxidative stress index (OSI: 92.25 ± 6.60 vs. 51.89 ± 6.45; < .001).
The presented data provide a justification to consider vitamin D as an important factor that could ameliorate disease severity through its anti-inflammatory and antioxidant effects.
COVID-19 的特征是存在氧化应激。维生素 D 状态已被认为是可能影响疾病严重程度的因素之一。本研究旨在评估住院 COVID-19 患者血清维生素 D 水平、氧化应激标志物与疾病严重程度之间的关系。
对 33 例 COVID-19 患者进行维生素 D 水平检测。测定血清总抗氧化能力和血浆过氧化物。
与中度组相比，重症 COVID-19 患者的维生素 D 水平较低（18.39±2.29ng/mL 比 28.47±3.05ng/mL， < .05），氧化应激更高。根据血清维生素 D 水平进行分组时，维生素 D 水平低于 30ng/mL 的组，LDH（604.8±76.98IU/mL 比 261.57±47.33IU/mL）和 D-二聚体（5978±2028ng/mL 比 977.7±172ng/mL）的数值明显更高，随后血浆过氧化物（d-ROMs：414.9±15.82U.Carr 比 352.4±18.77U.Carr； < .05）和氧化应激指数（OSI：92.25±6.60 比 51.89±6.45； < .001）也明显更高。
所提供的数据表明，维生素 D 可作为一种重要因素，通过其抗炎和抗氧化作用来改善疾病严重程度。
