Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai, Hongkou District, China.
Shanghai Jiao Tong University School of Medicine, Shanghai, Huangpu District, China.
BMJ Open Diabetes Res Care. 2021 Nov;9(2). doi: 10.1136/bmjdrc-2021-002321.
Exposure to antibiotics (ABX) during pregnancy can have a systematic effect on both fetal and maternal health. Although previous biomonitoring studies have indicated the effects on children of extensive exposure to ABX, studies on pregnant women remain scarce. To explore the effect on pregnant women of environmental exposure to ABX through accidental ingestion and identify potential health risks, the present study investigated 122 pregnant women in East China between 2019 and 2020.
The presence of six categories of ABX (quinolones, sulfonamides, lincosamides, tetracyclines, amide alcohol ABX, and β-lactams) in plasma samples taken from the pregnant women was investigated using an ABX kit and a time-resolved fluorescence immunoassay.
All six ABX were detected in the plasma, with a detection rate of 17.2%. It was discovered that the composition of intestinal flora in pregnant women exposed to ABX was different from that of pregnant women who had not been exposed to ABX. The intestinal flora of pregnant women exposed to ABX also changed at both the phylum and genus levels, and several genera almost disappeared. Furthermore, the metabolic levels of glucose and insulin and the alpha diversity of pregnant women exposed to ABX were higher than those of pregnant women not exposed to ABX.
Pregnant women are potentially at higher risk of adverse microbial effects. Glucose metabolism and insulin levels were generally higher in pregnant women exposed to ABX than in unexposed women. Also, the composition and color of the gut microbiome changed.
孕妇接触抗生素（ABX）可能会对胎儿和母体健康产生系统性影响。尽管之前的生物监测研究表明，广泛接触 ABX 会对儿童产生影响，但针对孕妇的研究仍然很少。为了通过意外摄入来探索孕妇接触 ABX 对环境的影响，并确定潜在的健康风险，本研究于 2019 年至 2020 年期间在华东地区调查了 122 名孕妇。
使用 ABX 试剂盒和时间分辨荧光免疫分析法检测来自孕妇的血浆样本中六种 ABX（喹诺酮类、磺胺类、林可酰胺类、四环素类、酰胺醇 ABX 和β-内酰胺类）的存在。
所有六种 ABX 均在血浆中被检测到，检出率为 17.2%。研究发现，暴露于 ABX 的孕妇的肠道菌群组成与未暴露于 ABX 的孕妇不同。暴露于 ABX 的孕妇的肠道菌群在门和属水平上也发生了变化，几个属几乎消失了。此外，暴露于 ABX 的孕妇的葡萄糖和胰岛素代谢水平以及 alpha 多样性高于未暴露于 ABX 的孕妇。
孕妇可能面临更高的不良微生物影响风险。暴露于 ABX 的孕妇的葡萄糖代谢和胰岛素水平普遍高于未暴露于 ABX 的孕妇。此外，肠道微生物组的组成和颜色发生了变化。
