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富硒枯草芽孢杆菌 yb-114246 通过改变回肠细菌组成来改善肉鸡的生长和免疫。

Selenium-enriched Bacillus subtilis yb-114246 improved growth and immunity of broiler chickens through modified ileal bacterial composition.

机构信息

School of Animal Husbandry and Veterinary Medicine, Jiangsu Vocational College of Agriculture and Forestry, Jurong, 212400, Jiangsu, China.

College of Animal Science and Technology, Chinese Agricultural University, Beijing, 100093, China.

出版信息

Sci Rep. 2021 Nov 4;11(1):21690. doi: 10.1038/s41598-021-00699-4.

DOI:10.1038/s41598-021-00699-4
PMID:34737359
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8568892/
Abstract

Here, a Selenium-enriched Bacillus subtilis (SEBS) strain was generated and supplemented to broiler chickens' diet, and the impact in ileum bacterial microbiome, immunity and body weight were assessed. In a nutshell, five hundred 1-old old chicken were randomly divided into five groups: control, inorganic Se, Bacillus subtilis (B. subtilis), SEBS, and antibiotic, and colonization with B. subtilis and SEBS in the gastrointestinal tract (GIT) were measured by fluorescence in situ hybridization (FISH) assay and quantitative real-time polymerase chain reaction (qPCR). In summary, Chicks fed SEBS or B. subtilis had higher body weight than the control chicks or those given inorganic Se. SEBS colonized in distal segments of the ileum improved bacterial diversity, reduced the endogenous pathogen burden and increased the number of Lactobacillus sp. in the ileal mucous membrane. Species of unclassified Lachnospiraceae, uncultured Anaerosporobacter, Peptococcus, Lactobacillus salivarius, and Ruminococcaceae_UCG-014, and unclassified Butyricicoccus in the ileal mucous membrane played a key role in promoting immunity. Inorganic Se supplementation also improved bacterial composition of ileal mucous membranes, but to a less extent. In conclusion, SEBS improved performance and immunity of broiler chickens through colonization and modulation of the ileal mucous membrane microbiome.

摘要

在这里，生成了一种富硒枯草芽孢杆菌（SEBS）菌株并添加到肉鸡饲料中，评估了其对回肠细菌微生物组、免疫力和体重的影响。简而言之，将 500 只 1 日龄的鸡随机分为五组：对照组、无机硒、枯草芽孢杆菌（B. subtilis）、SEBS 和抗生素，并通过荧光原位杂交（FISH）和定量实时聚合酶链反应（qPCR）测量 B. subtilis 和 SEBS 在胃肠道（GIT）中的定植。总之，饲喂 SEBS 或枯草芽孢杆菌的小鸡体重高于对照组小鸡或给予无机硒的小鸡。SEBS 定植在回肠远端段可提高细菌多样性，降低内源性病原体负担并增加回肠黏膜中乳杆菌属的数量。未分类的 Lachnospiraceae 种、未培养的 Anaerosporobacter、Peptococcus、Lactobacillus salivarius 和 Ruminococcaceae_UCG-014 以及回肠黏膜中的未分类 Butyricicoccus 在促进免疫方面发挥了关键作用。补充无机硒也改善了回肠黏膜的细菌组成，但程度较小。总之，SEBS 通过定植和调节回肠黏膜微生物组来提高肉鸡的性能和免疫力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ffb/8568892/2d675ecdd9c0/41598_2021_699_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ffb/8568892/82e9e42ca2ed/41598_2021_699_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ffb/8568892/4d117e8ec995/41598_2021_699_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ffb/8568892/b4f213abf9be/41598_2021_699_Fig3a_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ffb/8568892/fd93bb1efab5/41598_2021_699_Fig4a_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ffb/8568892/2a5a4803d8f8/41598_2021_699_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ffb/8568892/2d675ecdd9c0/41598_2021_699_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ffb/8568892/82e9e42ca2ed/41598_2021_699_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ffb/8568892/4d117e8ec995/41598_2021_699_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ffb/8568892/b4f213abf9be/41598_2021_699_Fig3a_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ffb/8568892/fd93bb1efab5/41598_2021_699_Fig4a_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ffb/8568892/2a5a4803d8f8/41598_2021_699_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ffb/8568892/2d675ecdd9c0/41598_2021_699_Fig6_HTML.jpg

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