Shirai Toshiyuki
Department of Accelerator and Medical Physics, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology.
Igaku Butsuri. 2021;41(3):122-126. doi: 10.11323/jjmp.41.3_122.
A charged particle therapy was proposed by Robert R. Wilson in 1946 and a clinical study of proton radiotherapy had been started at Lawrence Berkeley National Laboratory in 1954. Clinical studies have been promoted mainly in the United States and Europe. However, in Japan as well, the University of Tsukuba (KEK Campus) and the National Institute of Radiological Sciences (NIRS) started proton radiotherapy around 1980, and NIRS started carbon-ion radiotherapy in 1994. Following pioneering clinical studies, now in Japan, many proton and carbon-ion radiotherapy facilities are in operation, and some vendors are supplying equipment. Among them, charged particle therapy technologies originating in Japan have been developed, such as a respiratory-gated irradiation technology, a spot scanning irradiation technology, and a clinical dose design for ion radiotherapy. I look back on them and discuss the future direction of research and development of the charged particle therapy.
1946年，罗伯特·R·威尔逊提出了带电粒子疗法，1954年，劳伦斯伯克利国家实验室开始了质子放射治疗的临床研究。临床研究主要在美国和欧洲得到推进。然而，在日本，筑波大学（高能加速器研究机构校区）和日本国立放射医学综合研究所也于1980年左右开始了质子放射治疗，日本国立放射医学综合研究所于1994年开始了碳离子放射治疗。在开创性的临床研究之后，如今在日本，许多质子和碳离子放射治疗设施正在运行，一些供应商也在供应设备。其中，源自日本的带电粒子治疗技术已经得到发展，如呼吸门控照射技术、点扫描照射技术以及离子放射治疗的临床剂量设计。我回顾这些技术，并探讨带电粒子治疗的研发未来方向。
