Department of Immunology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran; Immunology Today, Universal Scientific Education and Research Network (USERN), Tehan, Iran.
Pathol Res Pract. 2021 Dec;228:153647. doi: 10.1016/j.prp.2021.153647. Epub 2021 Oct 12.
Coronavirus disease 2019 (COVID-19) is a viral disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is more serious in people with underlying diseases, but the cause of healthy people with progressive disease is largely unknown. Host genetic factors such as ACE2 variants, IFITM-3, HLA, TMRSS2, and furin polymorphisms appear to be one of the agents involved in the progression of the COVID-19 and outcome of the disease. This review discusses the general characteristics of SARS-CoV-2, including viral features, receptors, cell entry, clinical findings, and the main human genetic factors that may contribute to the pathogenesis of COVID-19 and get the patients' situation more complex. Further knowledge in this context may help to find a way to prevent and treat this viral pneumonia.
新型冠状病毒病（COVID-19）是由严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）引起的病毒性疾病。患有基础疾病的人病情更为严重，但健康人群病情进展的原因在很大程度上尚不清楚。宿主遗传因素，如 ACE2 变体、IFITM-3、HLA、TMRSS2 和弗林蛋白酶多态性，似乎是参与 COVID-19 进展和疾病结局的因素之一。这篇综述讨论了 SARS-CoV-2 的一般特征，包括病毒特征、受体、细胞进入、临床发现以及可能导致 COVID-19 发病机制和使患者病情更为复杂的主要人类遗传因素。在这方面进一步的知识可能有助于找到预防和治疗这种病毒性肺炎的方法。
