造血干细胞与再生
Hematopoietic Stem Cells and Regeneration.
机构信息
Department of Medicine, University of California San Diego, La Jolla, California 92093.
Department of Pharmacology, University of California San Diego, La Jolla, California 92093.
出版信息
Cold Spring Harb Perspect Biol. 2022 Aug 1;14(8):a040774. doi: 10.1101/cshperspect.a040774.
Abstract
Hematopoietic stem cell (HSC) regeneration is the remarkable process by which extremely rare, normally inactive cells of the bone marrow can replace an entire organ if called to do so by injury or harnessed by transplantation. HSC research is arguably the first quantitative single-cell science and the foundation of adult stem cell biology. Bone marrow transplant is the oldest and most refined technique of regenerative medicine. Here we review the intertwined history of the discovery of HSCs and bone marrow transplant, the molecular and cellular mechanisms of HSC self-renewal, and the use of HSCs and their derivatives for cell therapy.
摘要
造血干细胞（HSC）再生是一个显著的过程，骨髓中极少数通常处于静止状态的细胞，如果因损伤而被召唤，或者通过移植被利用，就可以替换整个器官。HSC 研究可以说是第一个定量的单细胞科学，也是成体干细胞生物学的基础。骨髓移植是再生医学中最古老、最完善的技术。在这里，我们回顾了 HSC 和骨髓移植的发现、HSC 自我更新的分子和细胞机制以及 HSC 及其衍生物在细胞治疗中的应用的历史。
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