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本文引用的文献

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Mapping circuit dynamics during function and dysfunction.在功能和功能障碍期间映射电路动态。
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2
Neuropeptide Modulation Increases Dendritic Electrical Spread to Restore Neuronal Activity Disrupted by Temperature.神经肽调节增加树突电传播,以恢复因温度而中断的神经元活动。
J Neurosci. 2021 Sep 8;41(36):7607-7622. doi: 10.1523/JNEUROSCI.0101-21.2021. Epub 2021 Jul 28.
3
Ion Channel Degeneracy, Variability, and Covariation in Neuron and Circuit Resilience.离子通道的多样性、变异性及其在神经元和回路中的协同变化与神经和回路的弹性。
Annu Rev Neurosci. 2021 Jul 8;44:335-357. doi: 10.1146/annurev-neuro-092920-121538. Epub 2021 Mar 26.
4
Neuronal oscillator robustness to multiple global perturbations.神经元振荡器对多种全局扰动的鲁棒性。
Biophys J. 2021 Apr 20;120(8):1454-1468. doi: 10.1016/j.bpj.2021.01.038. Epub 2021 Feb 18.
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Coupling between fast and slow oscillator circuits in is temperature-compensated.在 中,快振荡器电路和慢振荡器电路之间的耦合是温度补偿的。
Elife. 2021 Feb 4;10:e60454. doi: 10.7554/eLife.60454.
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Temperature compensation in a small rhythmic circuit.小节律性电路中的温度补偿。
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7
Rapid adaptation to elevated extracellular potassium in the pyloric circuit of the crab, .在蟹的幽门环中,细胞外钾的升高会迅速适应。
J Neurophysiol. 2020 May 1;123(5):2075-2089. doi: 10.1152/jn.00135.2020. Epub 2020 Apr 22.
8
Molecular profiling of single neurons of known identity in two ganglia from the crab .对蟹的两个神经节中已知身份的单个神经元进行分子分析。
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Robustness to Axon Initial Segment Variation Is Explained by Somatodendritic Excitability in Rat Substantia Nigra Dopaminergic Neurons.黑质多巴胺能神经元的树突体兴奋性解释了其对轴突起始段变化的鲁棒性。
J Neurosci. 2019 Jun 26;39(26):5044-5063. doi: 10.1523/JNEUROSCI.2781-18.2019. Epub 2019 Apr 26.
10
Visualization of currents in neural models with similar behavior and different conductance densities.具有相似行为但电导密度不同的神经模型中的电流可视化。
Elife. 2019 Jan 31;8:e42722. doi: 10.7554/eLife.42722.

从个体差异的神经科学到气候变化。

From the Neuroscience of Individual Variability to Climate Change.

机构信息

Volen Center and Biology Department, Brandeis University, Waltham, Massachusetts 02454

出版信息

J Neurosci. 2021 Dec 15;41(50):10213-10221. doi: 10.1523/JNEUROSCI.1261-21.2021. Epub 2021 Nov 9.

DOI:10.1523/JNEUROSCI.1261-21.2021
PMID:34753741
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8672684/
Abstract

Years of basic neuroscience on the modulation of the small circuits found in the crustacean stomatogastric ganglion have led us to study the effects of temperature on the motor patterns produced by the stomatogastric ganglion. While the impetus for this work was the study of individual variability in the parameters determining intrinsic and synaptic conductances, we are confronting substantial fluctuations in the stability of the networks to extreme temperature; these may correlate with changes in ocean temperature. Interestingly, when studied under control conditions, these wild-caught animals appear to be unchanged, but it is only when challenged by extreme temperatures that we reveal the consequences of warming oceans.

摘要

多年来,对甲壳类动物口胃神经节中小电路的调制的基础神经科学研究,使我们能够研究温度对由口胃神经节产生的运动模式的影响。虽然这项工作的动力是研究决定内在和突触电导率的参数的个体可变性,但我们正面临着网络对极端温度稳定性的大幅波动;这些波动可能与海洋温度的变化有关。有趣的是,当在对照条件下进行研究时,这些野生捕获的动物似乎没有变化,但只有在受到极端温度的挑战时,我们才会揭示海洋变暖的后果。