Minkoff S, Axelrod S
J Periodontol. 1987 Jul;58(7):470-4. doi: 10.1902/jop.1987.58.7.470.
Controlled stimuli were used to evaluate a commercially available dentifrice containing 10% strontium chloride hexahydrate for efficacy in alleviating the symptoms of uncomplicated dentinal hypersensitivity. Sixty-one subjects with hypersensitivity were included in the 12-week, double-blind, parallel, comparative (placebo) study. Levels of hypersensitivity in affected teeth were assessed by three methods: thermally controlled cold air stimulus, tactile stimulus with an electronic pressure sensitive probe, and subjective response. The results from all three methods of assessment indicated that the strontium chloride dentifrice, in comparison with a placebo, reduced dentinal hypersensitivity to a significantly greater degree. This therapeutic response to the active agent was apparent within 2 weeks and increased continuously thereafter for the length of the study. One can conclude that the regular at-home use of a dentifrice containing 10% strontium chloride hexahydrate is an effective means for reducing the discomfort and pain engendered by thermal and tactile stimuli in patients with dentinal hypersensitivity.
使用对照刺激来评估一种市售的含有10%六水合氯化锶的牙膏在缓解单纯性牙本质过敏症状方面的功效。61名患有过敏症的受试者被纳入了这项为期12周的双盲、平行、对照（安慰剂）研究。通过三种方法评估患牙的过敏程度：热控冷空气刺激、使用电子压力敏感探针的触觉刺激以及主观反应。所有三种评估方法的结果均表明，与安慰剂相比，含氯化锶牙膏能更显著地降低牙本质过敏。对活性剂的这种治疗反应在2周内就很明显，并且在研究期间持续增强。可以得出结论，在家中定期使用含有10%六水合氯化锶的牙膏是减轻牙本质过敏患者因热刺激和触觉刺激而产生的不适和疼痛的有效方法。
