Abrahamsson H
Scand J Gastroenterol Suppl. 1987;130:21-6. doi: 10.3109/00365528709090996.
Patients with the irritable bowel syndrome (IBS) often have symptoms from both proximal and distal parts of the gut. Motility disturbances have been reported to occur from the esophagus to the distal colon in IBS patients. The patients often have a decreased lower esophageal sphincter pressure and various abnormalities of esophageal peristalsis. Mean transit time in the small intestine after a meal is short in patients with diarrhoea, and long in patients with constipation and pain compared with normals. IBS patients also show abnormalities of the interdigestive MMC, particularly when exposed to stressful stimuli. Previous studies of the colonic oscillating control potential suggested an increased prevalence of 3/min. slow waves in IBS patients compared with normals, but later studies could not confirm this. Long time measurements with multiple electrodes along the colon show a high prevalence of short-lasting segmental contractions in constipated patients, while both short and long-lasting contractions are decreased in painless diarrhoea. Rectal recordings in IBS patients have shown an increased contractile response up to 3 hrs after a meal. --The disturbed gut motility in IBS patients seems to be due no neural influences rather than strictly myogenic factors.
肠易激综合征（IBS）患者的肠道近端和远端常常都会出现症状。据报道，IBS患者从食管到结肠远端都会出现运动功能紊乱。这些患者通常食管下括约肌压力降低，且存在各种食管蠕动异常。与正常人相比，腹泻型患者餐后小肠平均转运时间较短，便秘型和疼痛型患者的餐后小肠平均转运时间较长。IBS患者在消化间期的移行性复合运动（MMC）也表现异常，尤其是在受到应激刺激时。先前关于结肠振荡控制电位的研究表明，与正常人相比，IBS患者3次/分钟慢波的发生率增加，但后来的研究未能证实这一点。沿结肠使用多个电极进行长时间测量显示，便秘型患者短时间节段性收缩的发生率较高，而无痛性腹泻患者短时间和长时间收缩均减少。IBS患者的直肠记录显示，餐后3小时内收缩反应增强。——IBS患者肠道运动紊乱似乎并非严格由肌源性因素引起，而是由于神经影响。
