Liu Qi, Deng Jiali, Qiu Yan, Gao Juan, Li Jin, Guan Longfei, Lee Hangil, Zhou Qiulian, Xiao Junjie
Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong 226011, China.
Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Life Science, Shanghai University, Shanghai 200444, China.
Mol Ther Nucleic Acids. 2021 Oct 19;26:1066-1078. doi: 10.1016/j.omtn.2021.10.010. eCollection 2021 Dec 3.
Muscle atrophy is a common complication of many chronic diseases including heart failure, cancer cachexia, aging, etc. Unhealthy habits and usage of hormones such as dexamethasone can also lead to muscle atrophy. However, the underlying mechanisms of muscle atrophy are not completely understood. Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs), play vital roles in muscle atrophy. This review mainly discusses the regulation of ncRNAs in muscle atrophy induced by various factors such as heart failure, cancer cachexia, aging, chronic obstructive pulmonary disease (COPD), peripheral nerve injury (PNI), chronic kidney disease (CKD), unhealthy habits, and usage of hormones; highlights the findings of ncRNAs as common regulators in multiple types of muscle atrophy; and summarizes current therapies and underlying mechanisms for muscle atrophy. This review will deepen the understanding of skeletal muscle biology and provide new strategies and insights into gene therapy for muscle atrophy.
肌肉萎缩是包括心力衰竭、癌症恶病质、衰老等在内的许多慢性疾病的常见并发症。不健康的生活习惯以及使用地塞米松等激素也会导致肌肉萎缩。然而，肌肉萎缩的潜在机制尚未完全明确。非编码RNA（ncRNAs），如微小RNA（miRNAs）、长链非编码RNA（lncRNAs）和环状RNA（circRNAs），在肌肉萎缩中发挥着至关重要的作用。本综述主要讨论了ncRNAs在由心力衰竭、癌症恶病质、衰老、慢性阻塞性肺疾病（COPD）、周围神经损伤（PNI）、慢性肾脏病（CKD）、不健康生活习惯以及激素使用等各种因素诱导的肌肉萎缩中的调控作用；强调了ncRNAs作为多种类型肌肉萎缩共同调节因子的研究发现；并总结了目前针对肌肉萎缩的治疗方法及其潜在机制。本综述将加深对骨骼肌生物学的理解，并为肌肉萎缩的基因治疗提供新的策略和见解。
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