Teoh Jia Heng, Tay Sook Muay, Fuh Jerry, Wang Chi-Hwa
Department of Chemical and Biomolecular Engineering, National University of Singapore, 117585, Singapore.
Department of Surgical Intensive Care, Division of Anaesthesiology and Perioperative Medicine, Singapore General Hospital, Outram Road, 169608, Singapore.
J Control Release. 2022 Jan;341:80-94. doi: 10.1016/j.jconrel.2021.11.017. Epub 2021 Nov 15.
In recent times, 3D printing has been gaining traction as a fabrication platform for customizable drug dosages as a form of personalized medicine. While this has been recently demonstrated as oral dosages, there is potential to provide the same customizability and personalization as topical applications for wound healing. In this paper, the application of 3D printing to fabricate hydrogel wound dressings with customizable architectures and drug dosages was investigated. Chitosan methacrylate was synthesized and mixed with Lidocaine Hydrochloride and Levofloxacin respectively along with a photoinitiator before being used to print wound dressings of various designs. These designs were then investigated for their effect on drug release rates and profiles. Our results show the ability of 3D printing to customize drug dosages and drug release rates through co-loading different drugs at various positions and varying the thickness of drug-free layers over drug-loaded layers in the wound dressing respectively. Two scale-up approaches were also investigated for their effects on drug release rates from the wound dressing. The influence that each wound dressing design has on the release profile of drugs was also shown by fitting them with drug release kinetic models. This study thus shows the feasibility of utilizing 3D printing to fabricate wound dressings with customizable shapes, drug dosage and drug release rates that can be tuned according to the patient's requirements.
近年来，3D打印作为一种个性化医疗形式的可定制药物剂量制造平台，越来越受到关注。虽然最近已证明可用于口服剂量，但作为伤口愈合的局部应用，也有提供相同定制性和个性化的潜力。本文研究了3D打印在制造具有可定制结构和药物剂量的水凝胶伤口敷料中的应用。合成了甲基丙烯酸壳聚糖，并分别与盐酸利多卡因和左氧氟沙星以及光引发剂混合，然后用于打印各种设计的伤口敷料。接着研究了这些设计对药物释放速率和释放曲线的影响。我们的结果表明，3D打印能够通过在伤口敷料的不同位置共负载不同药物以及改变载药层上无药层的厚度，来定制药物剂量和药物释放速率。还研究了两种放大方法对伤口敷料药物释放速率的影响。通过将每种伤口敷料设计与药物释放动力学模型拟合，也显示了其对药物释放曲线的影响。因此，本研究表明利用3D打印制造具有可定制形状、药物剂量和药物释放速率的伤口敷料是可行的，这些可以根据患者的需求进行调整。
