依诺沙星和诺氟沙星对人体结肠微生物群的比较效应。
Comparative effects of enoxacin and norfloxacin on human colonic microflora.
作者信息
Edlund C, Lidbeck A, Kager L, Nord C E
机构信息
Department of Microbiology, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden.
出版信息
Antimicrob Agents Chemother. 1987 Nov;31(11):1846-8. doi: 10.1128/AAC.31.11.1846.
Abstract
Ten healthy volunteers received 400 mg of enoxacin and another ten healthy volunteers received 200 mg of norfloxacin orally twice a day for 7 days. Fecal specimens were collected before, during, and after drug administration to study the impact of enoxacin and norfloxacin on the normal colonic microflora. On day 7, the mean concentrations of enoxacin and norfloxacin were 350 and 950 mg/kg of feces, respectively. Enoxacin and norfloxacin affected the colonic microflora in similar ways. The number of strains of the family Enterobacteriaceae was markedly suppressed during drug administration, whereas the gram-positive and anaerobic microfloras were not significantly altered. Two weeks after withdrawal of the drugs, the colonic microflora had returned to normal.
摘要
十名健康志愿者每天口服两次400毫克依诺沙星，另外十名健康志愿者每天口服两次200毫克诺氟沙星，持续7天。在给药前、给药期间和给药后收集粪便样本，以研究依诺沙星和诺氟沙星对正常结肠微生物群的影响。在第7天，依诺沙星和诺氟沙星在粪便中的平均浓度分别为350毫克/千克和950毫克/千克。依诺沙星和诺氟沙星对结肠微生物群的影响方式相似。在给药期间，肠杆菌科菌株数量明显受到抑制，而革兰氏阳性菌和厌氧菌微生物群没有明显改变。停药两周后，结肠微生物群恢复正常。
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