Al Shakirchi Mahasin, Sorjonen Kimmo, Klingspor Lena, Bergman Peter, Hjelte Lena, de Monestrol Isabelle
Stockholm Cystic Fibrosis Centre, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden.
Department of Clinical Science, Intervention and Technology, Division of Pediatrics, Karolinska Institutet, 171 77 Stockholm, Sweden.
J Fungi (Basel). 2021 Nov 9;7(11):944. doi: 10.3390/jof7110944.
is commonly isolated from CF airways. However, the impact on CF lung progression is not completely understood. In this study, using a 16-year retrospective observational cohort study (2000-2015) that included 132 patients, we determined the annual lung function, measured as percent predicted forced expiratory volume in the first second (ppFEV1), decline before and after the first colonization with . Further, in the same individual, the ratios of lung function when patients were colonized with and when they were not were calculated. The impact of eradication, with antifungal treatment or spontaneously, was assessed. The annual ppFEV1 was significantly lower after the first colonization with . Furthermore, within the same individual, colonization with for two and three years in a row was associated with 4.3% and 7.9% lower ppFEV1, respectively, compared to when not colonized. Finally, patients who eradicated the following two years after colonization exhibited 9.9% and 14.5% higher ppFEV1 compared to patients who continued to produce cultures with for two and three years. Our study demonstrated that colonization was associated with a negative impact on lung function in the long term and eradication, spontaneously or with treatment, was associated with a better pulmonary outcome.
通常从囊性纤维化（CF）气道中分离得到。然而，其对CF肺部进展的影响尚未完全明确。在本研究中，我们采用一项为期16年的回顾性观察队列研究（2000 - 2015年），纳入了132例患者，测定了首次感染前后以第一秒用力呼气容积预测值百分比（ppFEV1）衡量的年度肺功能下降情况。此外，在同一患者个体中，计算了感染该病菌时与未感染时的肺功能比值。评估了通过抗真菌治疗或自然清除该病菌的影响。首次感染该病菌后，年度ppFEV1显著降低。此外，在同一患者个体中，连续两年和三年感染该病菌时的ppFEV1分别比未感染时低4.3%和7.9%。最后，与连续两年和三年持续培养出该病菌的患者相比，感染后两年内清除该病菌的患者ppFEV1分别高出9.9%和14.5%。我们的研究表明，长期来看，感染该病菌与肺功能的负面影响相关，而自然清除或经治疗清除则与更好的肺部预后相关。
