利用近红外荧光 AgInSe/ZnS 量子点诊断前列腺癌和前列腺炎。
Diagnosis of Prostate Cancer and Prostatitis Using near Infra-Red Fluorescent AgInSe/ZnS Quantum Dots.
机构信息
Department of Chemical Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, Johannesburg 2028, South Africa.
Centre for Nanomaterials Science Research, University of Johannesburg, P.O. Box 17011, Doornfontein, Johannesburg 2028, South Africa.
出版信息
Int J Mol Sci. 2021 Nov 19;22(22):12514. doi: 10.3390/ijms222212514.
The link between the microbiome and cancer has led researchers to search for a potential probe for intracellular targeting of bacteria and cancer. Herein, we developed near infrared-emitting ternary AgInSe/ZnS quantum dots (QDs) for dual bacterial and cancer imaging. Briefly, water-soluble AgInSe/ZnS QDs were synthesized in a commercial kitchen pressure cooker. The as-synthesized QDs exhibited a spherical shape with a particle diameter of 4.5 ± 0.5 nm, and they were brightly fluorescent with a photoluminescence maximum at 705 nm. The QDs showed low toxicity against mouse mammary carcinoma (FM3A-Luc), mouse colon carcinoma (C26), malignant fibrous histiocytoma-like (KM-Luc/GFP) and prostate cancer cells, a greater number of accumulations in , and good cellular uptake in prostate cancer cells. This work is an excellent step towards using ternary QDs for diagnostic and guided therapy for prostate cancer.
微生物组与癌症之间的联系促使研究人员寻找一种用于细菌和癌症细胞内靶向的潜在探针。在此，我们开发了近红外发射三元 AgInSe/ZnS 量子点（QD），用于双细菌和癌症成像。简要地说，水溶性 AgInSe/ZnS QD 是在商用压力锅中合成的。所合成的 QD 呈球形，粒径为 4.5 ± 0.5nm，具有 705nm 的光致发光最大发射峰，发光明亮。QD 对小鼠乳腺癌（FM3A-Luc）、小鼠结肠癌细胞（C26）、恶性纤维组织细胞瘤样（KM-Luc/GFP）和前列腺癌细胞的毒性较低，在前列腺癌细胞中积累更多，细胞摄取良好。这项工作朝着使用三元 QD 进行前列腺癌的诊断和引导治疗迈出了极好的一步。
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