Department of Hygiene and Preventive Medicine, Iwate Medical University, Yahaba 028-3694, Japan.
Department of Nursing Informatics, Graduate School of Nursing Science, St. Luke's International University, Tokyo 104-0044, Japan.
Nutrients. 2021 Oct 25;13(11):3781. doi: 10.3390/nu13113781.
We aimed to evaluate the association between the milk consumption and incident stroke in a Japanese population, where milk consumption is lower than that of Western countries. In total, 14,121 participants (4253 men and 9868 women) aged 40-69 years, free from cardiovascular diseases (CVD) were prospectively followed for 10.7 years. Participants were categorized into four groups according to the milk intake frequency obtained from a brief-type self-administered diet questionnaire. The adjusted HRs of total stroke, ischemic stroke and haemorrhagic stroke associated with milk intake frequency were calculated using the Cox proportional hazards model. During the follow-up, 478 stroke cases were detected (208 men and 270 women). Compared to women with a milk intake of <2 cups/week, those with an intake of 7 to <12 cups/week had a significantly low risk of ischemic stroke in a model adjusting CVD risk factors; the HR (95% CI) was 0.53 (0.32-0.88). No significant associations were found in men. This study suggested that milk intake of 7 to <12 cups/week decreased the risk of ischemic stroke in Japanese women. Milk intake of about 1 to <2 cups/day may be effective in the primary prevention of ischemic stroke in a population with low milk intake.
我们旨在评估日本人群中牛奶摄入与卒中事件之间的相关性，日本人群的牛奶摄入量低于西方国家。共有 14121 名（男性 4253 名，女性 9868 名）年龄在 40-69 岁、无心血管疾病（CVD）的参与者前瞻性随访了 10.7 年。参与者根据从简短型自我管理饮食问卷中获得的牛奶摄入量频率分为四组。使用 Cox 比例风险模型计算与牛奶摄入量频率相关的总卒中、缺血性卒中和出血性卒中的调整后 HR。在随访期间，共检测到 478 例卒中病例（男性 208 例，女性 270 例）。与每周牛奶摄入量<2 杯的女性相比，每周摄入 7-<12 杯的女性缺血性卒中风险显著降低；调整 CVD 危险因素后 HR（95%CI）为 0.53（0.32-0.88）。男性未发现显著相关性。这项研究表明，每周摄入 7-<12 杯牛奶可降低日本女性缺血性卒中的风险。对于牛奶摄入量低的人群，每天摄入约 1-<2 杯牛奶可能对缺血性卒中的一级预防有效。
