Department of Cardiology, The Fourth Hospital of Hebei Medical University, 12 Health Road, Shijiazhuang, Hebei, 050011, People's Republic of China.
Department of Orthopedics, The Fourth Hospital of Hebei Medical University, 12 Health Road, Shijiazhuang, Hebei, 050011, People's Republic of China.
BMC Cardiovasc Disord. 2021 Nov 26;21(1):565. doi: 10.1186/s12872-021-02331-9.
The diagnosis of malignant pericardial effusion (MPE) is often associated with a poor prognosis, but due to the complexity and unspecific nature of MPE patients' clinical manifestations, imaging often performs an essential role in diagnosis and prognosis.
Patients diagnosed with MPE between 2013 and 2018 at one tumor hospital were included and followed up. The data covered the basic clinical features, imaging findings, treatments and prognosis of patients with MPE, and the factors that may have affected the prognosis were explored.
A total of 216 patients with MPE were included with the median age of 60 years. The most common primary cancer type was lung cancer (73.6%), the most common symptom was dyspnea (62.9%) and the most common abnormal electrocardiogram finding was sinus tachycardia (42.1%). The median survival time of the 216 patients with MPE was 13.7 months. The factors affecting prognosis were echocardiographic fluid signs (HR = 2.37, P = 0.010), electrocardiographic evidence of sinus tachycardia (HR = 1.76, P = 0.006) and echocardiographic evidence of cardiac tamponade (HR = 3.33, P < 0.001).
MPE has complex clinical manifestations and an unsatisfactory prognosis. Echocardiographic fluid signs, electrocardiographic evidence of sinus tachycardia, and echocardiographic evidence of cardiac tamponade are independent risk factors affecting prognosis.
恶性心包积液（MPE）的诊断通常与预后不良相关，但由于 MPE 患者临床表现的复杂性和非特异性，影像学在诊断和预后中经常发挥重要作用。
纳入一家肿瘤医院 2013 年至 2018 年间诊断为 MPE 的患者并进行随访。该数据涵盖了 MPE 患者的基本临床特征、影像学表现、治疗和预后，探索了可能影响预后的因素。
共纳入 216 例 MPE 患者，中位年龄为 60 岁。最常见的原发性癌症类型是肺癌（73.6%），最常见的症状是呼吸困难（62.9%），最常见的异常心电图表现是窦性心动过速（42.1%）。216 例 MPE 患者的中位生存时间为 13.7 个月。影响预后的因素有心包积液超声征象（HR=2.37，P=0.010）、窦性心动过速的心电图证据（HR=1.76，P=0.006）和心包填塞的超声征象（HR=3.33，P<0.001）。
MPE 临床表现复杂，预后不佳。超声心动图积液征象、心电图窦性心动过速证据和超声心动图心包填塞证据是影响预后的独立危险因素。
