含氧化锌量子点的胶原蛋白与聚己内酯电纺支架用于皮肤伤口再生

Electrospun Scaffold of Collagen and Polycaprolactone Containing ZnO Quantum Dots for Skin Wound Regeneration.

作者信息

Li Pengfei, Ruan Liming, Wang Ruofan, Liu Tianqi, Song Gao, Gao Xiaofei, Jiang Guohua, Liu Xiaoyan

机构信息

School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018 China.

Department of Dermatology, Beilun People's Hospital of Ningbo City, Ningbo, 315800 China.

出版信息

J Bionic Eng. 2021;18(6):1378-1390. doi: 10.1007/s42235-021-00115-7. Epub 2021 Nov 22.

UNLABELLED

Nanofibers (NFs) have been widely used in tissue engineering such as wound healing. In this work, the antibacterial ZnO quantum dots (ZnO QDs) have been incorporated into the biocompatible poly (ε-caprolactone)/collagen (PCL/Col) fibrous scaffolds for wound healing. The as-fabricated PCL-Col/ZnO fibrous scaffolds exhibited good swelling, antibacterial activity, and biodegradation behaviors, which were beneficial for the applications as a wound dressing. Moreover, the PCL-Col/ZnO fibrous scaffolds showed excellent cytocompatibility for promoting cell proliferation. The resultant PCL-Col/ZnO fibrous scaffolds containing vascular endothelial growth factor (VEGF) also exhibited promoted wound-healing effect through promoting expression of transforming growth factor-β (TGF-β) and the vascular factor (CD31) in tissues in the early stages of wound healing. This new electrospun fibrous scaffolds with wound-healing promotion and antibacterial property should be convenient for treating wound healing.

SUPPLEMENTARY INFORMATION

The online version contains supplementary material available at 10.1007/s42235-021-00115-7.

未标注

纳米纤维（NFs）已广泛应用于组织工程，如伤口愈合。在本研究中，抗菌的氧化锌量子点（ZnO QDs）被掺入生物相容性聚（ε-己内酯）/胶原蛋白（PCL/Col）纤维支架中用于伤口愈合。制备的PCL-Col/ZnO纤维支架表现出良好的溶胀性、抗菌活性和生物降解行为，这有利于其作为伤口敷料的应用。此外，PCL-Col/ZnO纤维支架对促进细胞增殖表现出优异的细胞相容性。所得含有血管内皮生长因子（VEGF）的PCL-Col/ZnO纤维支架在伤口愈合早期还通过促进组织中转化生长因子-β（TGF-β）和血管因子（CD31）的表达表现出促进伤口愈合的效果。这种具有促进伤口愈合和抗菌性能的新型电纺纤维支架应便于治疗伤口愈合。