生物合成表皮生长因子促进表皮再生
Enhancement of epidermal regeneration by biosynthetic epidermal growth factor.
作者信息
Brown G L, Curtsinger L, Brightwell J R, Ackerman D M, Tobin G R, Polk H C, George-Nascimento C, Valenzuela P, Schultz G S
出版信息
J Exp Med. 1986 May 1;163(5):1319-24. doi: 10.1084/jem.163.5.1319.
Abstract
Epidermal regeneration depends on mitosis and migration of keratinocytes. Epidermal growth factor is known to stimulate growth of keratinocytes in vitro, thus it might be expected to promote wound healing. The results of this study show that topical application of biosynthetic human epidermal growth factor accelerates epidermal regeneration in split-thickness wounds and partial-thickness burns. The significant enhancement of epidermal regeneration suggests the potential for clinical use of epidermal growth factor for accelerating healing of burns, wounds from trauma, diabetic ulcers, skin graft donor sites, and others.
摘要
表皮再生依赖于角质形成细胞的有丝分裂和迁移。已知表皮生长因子在体外可刺激角质形成细胞的生长，因此可以预期它能促进伤口愈合。本研究结果表明，局部应用生物合成的人表皮生长因子可加速中厚皮伤口和浅度烧伤的表皮再生。表皮再生的显著增强表明表皮生长因子在临床上具有加速烧伤、创伤伤口、糖尿病溃疡、皮肤移植供区等愈合的潜在应用价值。
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