Ghafouri-Fard Soudeh, Shirvani-Farsani Zeinab, Hussen Bashdar Mahmud, Taheri Mohammad, Arefian Noormohammad
Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Cell and Molecular Biology, Faculty of Life Sciences and Technology, Shahid Beheshti University, Tehran, Iran.
Front Aging Neurosci. 2021 Nov 19;13:780489. doi: 10.3389/fnagi.2021.780489. eCollection 2021.
Ischemic stroke (IS) is an acute cerebral vascular event with high mortality and morbidity. Though the precise pathophysiologic routes leading to this condition are not entirely clarified, growing evidence from animal and human experiments has exhibited the impact of non-coding RNAs in the pathogenesis of IS. Various lncRNAs namely MALAT1, linc-SLC22A2, linc-OBP2B-1, linc_luo_1172, linc-DHFRL1-4, SNHG15, linc-FAM98A-3, H19, MEG3, ANRIL, MIAT, and GAS5 are possibly involved in the pathogenesis of IS. Meanwhile, lots of miRNAs contribute in this process. Differential expression of lncRNAs and miRNAs in the sera of IS patients versus unaffected individuals has endowed these transcripts the aptitude to distinguish at risk patients. Despite conduction of comprehensive assays for evaluation of the influence of lncRNAs/miRNAs in the pathogenesis of IS, therapeutic impacts of these transcripts in IS have not been clarified. In the present paper, we review the impact of lncRNAs/miRNAs in the pathobiology of IS through assessment of evidence provided by human and animal studies.
缺血性中风（IS）是一种死亡率和发病率都很高的急性脑血管事件。尽管导致这种疾病的确切病理生理途径尚未完全阐明，但来自动物和人体实验的越来越多的证据表明非编码RNA在IS的发病机制中具有重要作用。多种长链非编码RNA，即MALAT1、linc-SLC22A2、linc-OBP2B-1、linc_luo_1172、linc-DHFRL1-4、SNHG15、linc-FAM98A-3、H19、MEG3、ANRIL、MIAT和GAS5可能参与了IS的发病机制。与此同时，许多微小RNA也在这一过程中发挥作用。与未受影响个体相比，IS患者血清中长链非编码RNA和微小RNA的差异表达使这些转录本有能力区分高危患者。尽管已经进行了全面的分析来评估长链非编码RNA/微小RNA在IS发病机制中的影响，但这些转录本在IS中的治疗作用尚未阐明。在本文中，我们通过评估人类和动物研究提供的证据，综述了长链非编码RNA/微小RNA在IS病理生物学中的作用。
