Yang Wenling, Lin Jibin, Zhou Jin, Zheng Yuqi, Jiang Shijiu, He Shaolin, Li Dazhu
Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Immunol. 2021 Nov 11;12:758272. doi: 10.3389/fimmu.2021.758272. eCollection 2021.
Myocardial infarction results from obstruction of a coronary artery that causes insufficient blood supply to the myocardium and leads to ischemic necrosis. It is one of the most common diseases threatening human health and is characterized by high morbidity and mortality. Atherosclerosis is the pathological basis of myocardial infarction, and its pathogenesis has not been fully elucidated. Innate lymphoid cells (ILCs) are an important part of the human immune system and participate in many processes, including inflammation, metabolism and tissue remodeling, and play an important role in atherosclerosis. However, their specific roles in myocardial infarction are unclear. This review describes the current understanding of the relationship between innate lymphoid cells and myocardial infarction during the acute phase of myocardial infarction, myocardial ischemia-reperfusion injury, and heart repair and regeneration following myocardial infarction. We suggest that this review may provide new potential intervention targets and ideas for treatment and prevention of myocardial infarction.
心肌梗死是由冠状动脉阻塞导致心肌供血不足并引发缺血性坏死所致。它是威胁人类健康的最常见疾病之一，具有高发病率和高死亡率的特点。动脉粥样硬化是心肌梗死的病理基础，其发病机制尚未完全阐明。固有淋巴细胞（ILCs）是人体免疫系统的重要组成部分，参与包括炎症、代谢和组织重塑在内的许多过程，在动脉粥样硬化中发挥重要作用。然而，它们在心肌梗死中的具体作用尚不清楚。本综述描述了目前对固有淋巴细胞与心肌梗死急性期、心肌缺血再灌注损伤以及心肌梗死后心脏修复和再生之间关系的理解。我们认为，本综述可能为心肌梗死的治疗和预防提供新的潜在干预靶点和思路。
