Rhazouani Asmaa, Aziz Khalid, Gamrani Halima, Gebrati Lhoucine, Uddin Md Sahab, Faissal Aziz
Laboratory of Water, Biodiversity & Climate Change, Faculty of Sciences Semlalia, Cadi Ayyad University, B.P. 2390, 40000, Marrakech, Morocco.
Team of Neurosciences, Pharmacology and Environment (ENPE), Faculty of Sciences Semlalia, Cadi Ayyad University, Marrakech, Morocco.
Curr Res Pharmacol Drug Discov. 2021;2:100062. doi: 10.1016/j.crphar.2021.100062. Epub 2021 Oct 5.
COVID-19 is an infectious disease that affects the respiratory system and is caused by the novel coronavirus SARS-CoV-2. It was first reported in Wuhan, China, on December 31, 2019, and has affected the entire world. This pandemic has caused serious health, economic and social problems. In this situation, the only solution to combat COVID-19 is to accelerate the development of antiviral drugs and vaccines to mitigate the virus and develop better antiviral methods and excellent diagnostic and prevention techniques. With the development of nanotechnology, nanoparticles are being introduced to control COVID-19. Graphene oxide (GO), an oxidized derivative of graphene, is currently used in the medical field to treat certain diseases such as cancer. It is characterized by very important antiviral properties that allow its use in treating certain infectious diseases. The GO antiviral mechanism is discussed by the virus inactivation and/or the host cell receptor or by the physicochemical destruction of viral species. Moreover, the very high surface/volume ratio of GO allows the fixation of biomolecules by simple absorption. This paper summarizes the different studies performed on GO's antiviral activities and discusses GO-based biosensors for virus detection and approaches for prevention.
新型冠状病毒肺炎（COVID-19）是一种影响呼吸系统的传染病，由新型冠状病毒SARS-CoV-2引起。2019年12月31日首次在中国武汉报告，现已波及全球。这场大流行引发了严重的健康、经济和社会问题。在这种情况下，对抗新型冠状病毒肺炎的唯一解决办法是加速抗病毒药物和疫苗的研发，以减轻病毒危害，并开发更好的抗病毒方法以及出色的诊断和预防技术。随着纳米技术的发展，纳米颗粒正被用于对抗新型冠状病毒肺炎。氧化石墨烯（GO）是石墨烯的一种氧化衍生物，目前在医学领域用于治疗某些疾病，如癌症。它具有非常重要的抗病毒特性，使其可用于治疗某些传染病。氧化石墨烯的抗病毒机制可通过病毒灭活和/或宿主细胞受体，或通过病毒种类的物理化学破坏来探讨。此外，氧化石墨烯非常高的表面/体积比使其能够通过简单吸附固定生物分子。本文总结了对氧化石墨烯抗病毒活性的不同研究，并讨论了基于氧化石墨烯的病毒检测生物传感器及预防方法。
