School of Mechatronic Engineering, Xi'an Technological University, Xi'an, 710021, China.
Mechanical Engineering Department, University of Technology, Baghdad, Iraq.
Sci Rep. 2021 Dec 6;11(1):23479. doi: 10.1038/s41598-021-02937-1.
In this study, a simple and green strategy was reported to prepare bimetallic nanoparticles (NPs) by the combination of zinc oxide (ZnO) and copper oxide (CuO) using Sambucus nigra L. extract. The physicochemical properties of these NPs such as crystal structure, size, and morphology were studied by X-ray diffraction (XRD), field emission gun scanning electron microscopy (FEG-SEM), and transmission electron microscopy (TEM). The results suggested that these NPs contained polygonal ZnO NPs with hexagonal phase and spherical CuO NPs with monoclinic phase. The anticancer activity of the prepared bimetallic NPs was evaluated against lung and human melanoma cell lines based on MTT assay. As a result, the bimetallic ZnO/CuO NPs exhibited high toxicity on melanoma cancer cells while their toxicity on lung cancer cells was low.
在这项研究中，报告了一种简单环保的策略，使用接骨木（Sambucus nigra L.）提取物将氧化锌（ZnO）和氧化铜（CuO）组合制备双金属纳米粒子（NPs）。通过 X 射线衍射（XRD）、场发射枪扫描电子显微镜（FEG-SEM）和透射电子显微镜（TEM）研究了这些 NPs 的物理化学性质，如晶体结构、尺寸和形态。结果表明，这些 NPs 包含具有六方相的多面 ZnO NPs 和具有单斜相的球形 CuO NPs。基于 MTT 测定法，评估了制备的双金属 NPs 对肺癌和人黑色素瘤细胞系的抗癌活性。结果表明，双金属 ZnO/CuO NPs 对黑色素瘤癌细胞具有高毒性，而对肺癌细胞的毒性较低。
