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丁酸产生菌在慢性肾脏病中减少。

Butyrate producing microbiota are reduced in chronic kidney diseases.

机构信息

School of Marine Sciences, Nanjing University of Information Science and Technology, Nanjing, 210044, China.

Kaleido Biosciences, Lexington, MA, USA.

出版信息

Sci Rep. 2021 Dec 7;11(1):23530. doi: 10.1038/s41598-021-02865-0.

DOI:10.1038/s41598-021-02865-0
PMID:34876615
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8651744/
Abstract

Chronic kidney disease is a major public health concern that affects millions of people globally. Alterations in gut microbiota composition have been observed in patients with chronic kidney disease. Nevertheless, the correlation between the gut microbiota and disease severity has not been investigated. In this study, we performed shot-gun metagenomics sequencing and identified several taxonomic and functional signatures associated with disease severity in patients with chronic kidney disease. We noted that 19 microbial genera were significantly associated with the severity of chronic kidney disease. The butyrate-producing bacteria were reduced in patients with advanced stages of chronic kidney diseases. In addition, functional metagenomics showed that two-component systems, metabolic activity and regulation of co-factor were significantly associated with the disease severity. Our study provides valuable information for the development of microbiota-oriented therapeutic strategies for chronic kidney disease.

摘要

慢性肾脏病是一个重大的公共卫生关注点，影响着全球数百万人。在慢性肾脏病患者中观察到肠道微生物群落组成的改变。然而，肠道微生物群与疾病严重程度之间的相关性尚未得到研究。在这项研究中，我们进行了 shotgun 宏基因组测序，鉴定出与慢性肾脏病患者疾病严重程度相关的几个分类和功能特征。我们注意到，有 19 个微生物属与慢性肾脏病的严重程度显著相关。在慢性肾脏病晚期患者中，产生丁酸的细菌减少。此外，功能宏基因组学表明，二组分系统、代谢活性和辅因子调节与疾病严重程度显著相关。我们的研究为开发针对慢性肾脏病的以微生物组为导向的治疗策略提供了有价值的信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8fb/8651744/6eba0b37d56e/41598_2021_2865_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8fb/8651744/294939587634/41598_2021_2865_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8fb/8651744/1cec55e71e66/41598_2021_2865_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8fb/8651744/31edc12a4dcc/41598_2021_2865_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8fb/8651744/6ebd62c63bc2/41598_2021_2865_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8fb/8651744/5602c591caf3/41598_2021_2865_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8fb/8651744/3a4488c5928b/41598_2021_2865_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8fb/8651744/6eba0b37d56e/41598_2021_2865_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8fb/8651744/294939587634/41598_2021_2865_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8fb/8651744/1cec55e71e66/41598_2021_2865_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8fb/8651744/31edc12a4dcc/41598_2021_2865_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8fb/8651744/6ebd62c63bc2/41598_2021_2865_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8fb/8651744/5602c591caf3/41598_2021_2865_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8fb/8651744/3a4488c5928b/41598_2021_2865_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8fb/8651744/6eba0b37d56e/41598_2021_2865_Fig7_HTML.jpg

相似文献

[1]
Butyrate producing microbiota are reduced in chronic kidney diseases.

Sci Rep. 2021-12-7

[2]
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[3]
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Front Cell Infect Microbiol. 2019-6-12

[4]
Association between butyrate-producing gut bacteria and the risk of infectious disease hospitalisation: results from two observational, population-based microbiome studies.

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[5]
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[6]
A reduction in the butyrate producing species Roseburia spp. and Faecalibacterium prausnitzii is associated with chronic kidney disease progression.

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[7]
Dysbiosis of Gut Microbiota in Patients with Chronic Kidney Disease.

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[8]
[Gut microbiota in renal transplant recipients, patients with chronic kidney disease and healthy subjects].

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[9]
Alteration of the gut microbiota in Chinese population with chronic kidney disease.

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[10]
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引用本文的文献

[1]
Type 2 Diabetes and the Multifaceted Gut-X Axes.

Nutrients. 2025-8-21

[2]
Characterization of gut dysbiosis and intestinal barrier dysfunction in patients with metabolic dysfunction-associated steatotic liver disease and chronic kidney disease: a comparative study.

Sci Rep. 2025-5-3

[3]
The role of the intestinal microbiome in cognitive decline in patients with kidney disease.

Nephrol Dial Transplant. 2025-3-13

[4]
Beneficial Effects of Butyrate on Kidney Disease.

Nutrients. 2025-2-22

[5]
Gut microbiota and kidney function in autosomal dominant polycystic kidney disease participants in Cameroon: a cross-sectional study.

BMC Nephrol. 2025-1-13

[6]
Gut Dysbiosis and Its Role in the Anemia of Chronic Kidney Disease.

Toxins (Basel). 2024-11-17

[7]
Pathogenesis of Sarcopenia in Chronic Kidney Disease-The Role of Inflammation, Metabolic Dysregulation, Gut Dysbiosis, and microRNA.

Int J Mol Sci. 2024-8-3

[8]
A prospective pilot study of gut microbiome in cerebral vasospasm and delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage.

Sci Rep. 2024-7-30

[9]
The Role of Short Chain Fatty Acids in Inflammation and Body Health.

Int J Mol Sci. 2024-7-5

[10]
Role of the gut microbiota in cefoperazone/sulbactam-induced epilepsy in mice with chronic renal failure.

Ren Fail. 2024-12

本文引用的文献

[1]
Multivariable association discovery in population-scale meta-omics studies.

PLoS Comput Biol. 2021-11

[2]
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PLoS One. 2019-7-18

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Alterations to the Gut Microbiota and Their Correlation With Inflammatory Factors in Chronic Kidney Disease.

Front Cell Infect Microbiol. 2019-6-12

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Gut Microbes. 2016-5-3

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