Khodavirdipour Amir, Asadimanesh Mahsa, Masoumi Seyed Alireza
Department of Molecular Genetics, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Private Practice, Hamedan, Iran.
Glob Med Genet. 2021 Sep 16;8(4):183-185. doi: 10.1055/s-0041-1735538. eCollection 2021 Dec.
Nonsegmented positive-sense RNA enveloped RNA severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus can result in coronavirus disease 2019 (COVID-19). This virus is from β-coronaviridae family of viruses. The common signs and symptoms of COVID-19 include pyrexia, cough, dyspnea, fatigue, myalgia, cephalgia, diarrhea, and nausea. Physicians and dentists around the world could directly link the COVID-19 and oral diseases such as ageusia and anosmia. After time passes, different aspects of symptoms of the diseases have been discovered. Research suggests that the oral cavity is the most vulnerable region for the virus because of angiotensin-converting enzyme-2 (ACE2) receptor abundance in the mouth. In this case report (no. of patients = 6), we would like to report significant findings in patients who were diagnosed with COVID-19 reported to our clinic during May 2021 complaining about the oral manifestation of it such as xerostomia, gingival inflammation, and cracked teeth. All patients are younger than 40 years with no history of dental complaints and oral diseases. Fortunately, these symptoms are not life threatening and treatable/manageable by current treatment options. To date, there is no clear proof of how and via which pathway, SARS-CoV-2 genomic blueprint causes the oral manifestation of COVID-19 beside ACE2 receptor which is the only known biopathway for such incidents.
非分段正链RNA包膜的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）可导致2019冠状病毒病（COVID-19）。这种病毒属于β冠状病毒科。COVID-19的常见体征和症状包括发热、咳嗽、呼吸困难、疲劳、肌痛、头痛、腹泻和恶心。世界各地的医生和牙医可以直接将COVID-19与味觉丧失和嗅觉丧失等口腔疾病联系起来。随着时间的推移，人们发现了该疾病症状的不同方面。研究表明，由于口腔中血管紧张素转换酶2（ACE2）受体丰富，口腔是该病毒最易感染的区域。在本病例报告（患者数量=6）中，我们报告了2021年5月期间到我们诊所就诊的COVID-19确诊患者的重要发现，这些患者抱怨其口腔表现，如口干、牙龈炎症和牙齿裂纹。所有患者年龄均小于40岁，无牙科主诉和口腔疾病史。幸运的是，这些症状不会危及生命，目前的治疗方案可以治疗/控制。迄今为止，除了ACE2受体（这是此类事件唯一已知的生物途径）外，尚无明确证据表明SARS-CoV-2基因组蓝图如何以及通过何种途径导致COVID-19的口腔表现。
