Cuttler Jerry M, Calabrese Edward J
Cuttler & Associates Inc., Vaughan, ON, Canada.
Department of Environmental Health Sciences, University of Massachusetts Amherst, Amherst, MA, USA.
Dose Response. 2021 Nov 26;19(4):15593258211059317. doi: 10.1177/15593258211059317. eCollection 2021 Oct-Dec.
The 1953 Atoms for Peace Speech to the United Nations proposed applying nuclear energy to essential needs, including abundant electrical energy. The widespread fear of ionizing radiation from nuclear facilities and medical procedures began after the United States National Academy of Sciences performed a study of radiation dangers to the human genome. This study, initiated and managed by an oil industry benefactor, recommended in 1956 that the risk of radiation-induced mutations be assessed using the linear no-threshold dose-response model instead of the threshold model. It was followed by a study that wrongly linked low radiation to cancer among the atomic bomb survivors. The ensuing controversy resulted in a compromise. The National Committee on Radiation Protection adopted the precautionary principle policy in 1959, justified by fear of cancer and lack of knowledge. The United States and all other countries followed this recommendation, which remains unchanged 62 years later. Its impact on nuclear energy and medicine has been profound. Many costly regulations have been enacted to prevent very unlikely human or equipment failures-failures that would lead to radiation exposures that are below the dose thresholds for lasting harmful effects. Potential low-dose radiation therapies, against inflammation, cancer, autoimmune, and neurodegenerative diseases, are shunned.
1953年在联合国发表的“原子用于和平”演讲提议将核能应用于包括丰富电能在内的基本需求。在美国国家科学院对核设施和医疗程序产生的电离辐射危害进行研究之后,人们开始普遍担心电离辐射。这项由一位石油行业资助者发起并管理的研究在1956年建议使用线性无阈剂量反应模型而非阈模型来评估辐射诱发突变的风险。随后的一项研究错误地将低剂量辐射与原子弹幸存者中的癌症联系起来。随之而来的争议导致了一种折衷方案。国家辐射防护委员会于1959年采用了预防原则政策,理由是担心癌症以及缺乏相关知识。美国和所有其他国家都遵循了这一建议,62年后该建议仍未改变。它对核能和医学产生了深远影响。为防止极不可能发生的人员或设备故障(这些故障会导致低于产生持久有害影响剂量阈值的辐射暴露),已经制定了许多代价高昂的规定。针对炎症、癌症、自身免疫性疾病和神经退行性疾病的潜在低剂量辐射疗法被回避。