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放射肿瘤学中基于光学表面扫描的刚体运动监测的几何分析

Geometrical analysis for motion monitoring of rigid bodies with optical surface scanning in radiation oncology.

作者信息

Dekker Janita, van Wagenberg Teun Pieter, de Smet Mariska, Essers Marion, Kusters Martijn, de Kruijf Willy

机构信息

Instituut Verbeeten, Klinische Fysica & Instrumentatie, Postbus 90120, 5000 LA Tilburg, The Netherlands.

Department of Biomedical Engineering, Eindhoven University of Technology, Den Dolech 2, 5612 AZ Eindhoven, The Netherlands.

出版信息

Phys Imaging Radiat Oncol. 2021 Nov 30;20:105-110. doi: 10.1016/j.phro.2021.11.006. eCollection 2021 Oct.

Abstract

BACKGROUND AND PURPOSE

Surface guided radiotherapy can be used to improve patient setup and for accurate intra-fraction motion monitoring in correspondence to the isocenter. For a clinical relevant motion analysis the actual displacement of the entire clinical target volume (CTV) is necessary. Therefore, the aim of this study was to develop a novel assessment method for intra-fraction motion for rigid body structures based on motion data and a geometrical analysis.

MATERIALS AND METHODS

A threshold value on the volume coverage (VC(t)) of the CTV by the planning target volume (PTV) was proposed as online motion monitoring method. Moreover, offline analysis was performed by using heat maps and by calculating VCx, the volume coverage for at least x% of treatment time. The method was applied retrospectively to patient treatment data for whole brain radiation treatment without a thermoplastic mask.

RESULTS

In 132 out of 142 fractions in total the proportion of the CTV that was inside the PTV for at least 99% of the time (VC99) was more than 95%, for a CTV-to-PTV margin of 5 mm. The source-voxel heat map showed which part of the CTV had a reduced coverage and the target heat map showed the movement of the CTV.

CONCLUSION

Instead of using an action threshold on the movements of the isocenter, a threshold on the VC(t) of the CTV by the PTV was proposed. The heat maps and resulting values of VCx can be used to adapt the VC(t) threshold or the CTV-to-PTV margin for subsequent fractions.

摘要

背景与目的

表面引导放疗可用于改善患者摆位,并对应等中心进行精确的分次内运动监测。对于临床相关的运动分析,整个临床靶区(CTV)的实际位移是必要的。因此,本研究的目的是基于运动数据和几何分析,开发一种针对刚体结构的分次内运动的新型评估方法。

材料与方法

提出了计划靶区(PTV)对CTV的体积覆盖(VC(t))阈值作为在线运动监测方法。此外,通过使用热图和计算VCx(至少x%治疗时间的体积覆盖)进行离线分析。该方法被回顾性应用于无热塑性面罩的全脑放射治疗患者的治疗数据。

结果

在总共142个分次中的132个分次中,对于5mm的CTV到PTV边界,CTV在PTV内至少99%时间的比例(VC99)超过95%。源体素热图显示了CTV覆盖减少的部分,靶区热图显示了CTV的运动。

结论

提出了用PTV对CTV的VC(t)阈值代替对等中心运动使用动作阈值。热图和得到的VCx值可用于调整后续分次的VC(t)阈值或CTV到PTV的边界。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/beda/8640514/dcfb3a0db4dd/gr1.jpg

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