Swiss Eye Institute and Clinic for Vitreoretinal Diseases, Berner Augenklinik am Lindenhofspital, Bern, Switzerland.
Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Sci Rep. 2021 Dec 14;11(1):23989. doi: 10.1038/s41598-021-03294-9.
The specific changes linked to de novo development of postoperative PVR have remained elusive and were the object of the underlying study. Vitreous fluid (VF) was obtained at the beginning of vitrectomy from 65 eyes that underwent vitrectomy for primary rhegmatogenous retinal detachment (RRD) without preoperative PVR. Eyes developing postoperative PVR within 6 months after re-attachment surgery were compared to those which did not regarding the preoperative concentrations of 43 cytokines and chemokines in the VF, using multiplex beads analysis. For all comparisons Holm's correction was applied in order to control for multiple comparisons. Twelve out of 65 eyes (18.5%) developed PVR postoperatively. While 12 of the chemokines and cytokines presented concentration differences on a statistical level of p < 0.05 (CXCL5, CCL11, CCL24, CCL26, GM-CSF, IFN-γ, CCL8, CCL7, MIF, MIG/CXCL9, CCL19, and CCL25), CXCL5 was the only cytokine with sufficiently robust difference in its VF concentrations to achieve significance in eyes developing postoperative PVR compared to eyes without PVR. CXCL5 may represent a potent biomarker for the de novo development of postoperative PVR. In line with its pathophysiological role in the development of PVR, it might serve as a basis for the development of urgently needed preventive options.
玻璃体（VF）是在 65 只接受原发性孔源性视网膜脱离（RRD）玻璃体切除术而无术前 PVR 的眼中，在玻璃体切除术开始时获得的。比较了术后 6 个月内发生术后 PVR 的眼与未发生术后 PVR 的眼之间，VF 中 43 种细胞因子和趋化因子的术前浓度，采用多重珠分析。为了控制多次比较，对所有比较均应用 Holm 校正。在 65 只眼中，有 12 只（18.5%）发生了术后 PVR。虽然 12 种趋化因子和细胞因子在统计学上存在浓度差异（p<0.05）（CXCL5、CCL11、CCL24、CCL26、GM-CSF、IFN-γ、CCL8、CCL7、MIF、MIG/CXCL9、CCL19 和 CCL25），但只有 CXCL5 在其 VF 浓度上具有足够显著的差异，与未发生 PVR 的眼相比，在发生术后 PVR 的眼中达到了显著水平。CXCL5 可能是术后 PVR 新发病的潜在生物标志物。鉴于其在 PVR 发展中的病理生理作用，它可能成为急需的预防措施的基础。
