Kazyumba G, Berney M, Brighouse G, Cruchaud A, Lambert P H
Clin Exp Immunol. 1986 Jul;65(1):10-8.
The relative importance of polyclonal B cell activation has been studied in relation to the development of autoantibodies in human African trypanosomiasis. In 34 patients investigated before specific treatment a broad expression of the B cell repertoire was observed including the production of anti-hapten (FITC, Penicillin, Phosphorylcholin) antibodies, of high levels of antibodies against some heterologous protein antigens (ovalbumin and tetanus toxoid) and of autoantibodies. Anti-ssDNA antibodies were detected in 84% of the patients and anti-IgG rheumatoid factors in 88%. Anti-striated muscle and anti-smooth muscle antibodies were also observed in 57 and 63% of the patients. Correlation analysis indicated that the formation of anti-DNA antibodies is associated with polyclonal B cell activation but probably depends on an additional B cell stimulation by released DNA or cross-reacting antigens. Anti-immunoglobulin antibodies are closely correlated with polyclonal B cell activation and their production is likely to reflect the high frequency of anti-IgG B cell precursors in the normal human B cell repertoire. The significance of these observations in relation to the pathological expression of trypanosomiasis should be particularly considered in the generation of immune complexes either in circulating blood or locally at the sites of parasite destruction.
关于人类非洲锥虫病中自身抗体的产生，人们已对多克隆B细胞激活的相对重要性进行了研究。在34例接受特异性治疗前接受调查的患者中，观察到B细胞库广泛表达，包括抗半抗原（异硫氰酸荧光素、青霉素、磷酰胆碱）抗体、针对某些异源蛋白质抗原（卵清蛋白和破伤风类毒素）的高水平抗体以及自身抗体的产生。84%的患者检测到抗单链DNA抗体，88%的患者检测到抗IgG类风湿因子。57%和63%的患者还观察到抗横纹肌和抗平滑肌抗体。相关性分析表明，抗DNA抗体的形成与多克隆B细胞激活有关，但可能取决于释放的DNA或交叉反应抗原对B细胞的额外刺激。抗免疫球蛋白抗体与多克隆B细胞激活密切相关，其产生可能反映了正常人B细胞库中抗IgG B细胞前体的高频率。在循环血液中或寄生虫破坏部位局部产生免疫复合物时，应特别考虑这些观察结果与锥虫病病理表现的关系。
