Chanachai Supachai, Chaichana Wirinrat, Insee Kanlaya, Benjakul Sutiwa, Aupaphong Visakha, Panpisut Piyaphong
Division of Orthodontics, Faculty of Dentistry, Thammasat University, Pathum Thani 12120, Thailand.
Division of Oral Biology, Faculty of Dentistry, Thammasat University, Pathum Thani 12120, Thailand.
J Funct Biomater. 2021 Dec 10;12(4):73. doi: 10.3390/jfb12040073.
Enamel demineralization around orthodontic adhesive is a common esthetic concern during orthodontic treatment. The aim of this study was to prepare orthodontic adhesives containing monocalcium phosphate monohydrate (MCPM) and nisin to enable mineralizing and antibacterial actions. The physicomechanical properties and the inhibition of growth of the adhesives with added MCPM (5, 10 wt %) and nisin (5, 10 wt %) were examined. Transbond XT (Trans) was used as the commercial comparison. The adhesive containing a low level of MCPM showed significantly higher monomer conversion (42-62%) than Trans (38%) ( < 0.05). Materials with additives showed lower monomer conversion ( < 0.05), biaxial flexural strength ( < 0.05), and shear bond strength to enamel than those of a control. Additives increased water sorption and solubility of the experimental materials. The addition of MCPM encouraged Ca and P ion release, and the precipitation of calcium phosphate at the bonding interface. The growth of in all the groups was comparable ( > 0.05). In conclusion, experimental orthodontic adhesives with additives showed comparable conversion but lesser mechanical properties than the commercial material. The materials showed no antibacterial action, but exhibited ion release and calcium phosphate precipitation. These properties may promote remineralization of the demineralized enamel.
正畸治疗期间，正畸黏结剂周围的牙釉质脱矿是一个常见的美学问题。本研究的目的是制备含有一水磷酸二氢钙（MCPM）和乳酸链球菌素的正畸黏结剂，以实现矿化和抗菌作用。研究了添加MCPM（5%、10%重量）和乳酸链球菌素（5%、10%重量）的黏结剂的物理力学性能及其对生长的抑制作用。使用Transbond XT（Trans）作为商业对照。含有低水平MCPM的黏结剂的单体转化率（42%-62%）显著高于Trans（38%）（P<0.05）。与对照组相比，添加添加剂的材料的单体转化率（P<0.05）、双轴弯曲强度（P<0.05）和与牙釉质的剪切粘结强度较低。添加剂增加了实验材料的吸水率和溶解度。添加MCPM促进了钙和磷离子的释放，以及粘结界面处磷酸钙的沉淀。所有组中细菌的生长情况相当（P>0.05）。总之，添加添加剂的实验性正畸黏结剂显示出可比的转化率，但力学性能低于商业材料。这些材料没有抗菌作用，但表现出离子释放和磷酸钙沉淀。这些特性可能促进脱矿牙釉质的再矿化。
