Department of Science, City University of New York Borough of Manhattan Community College, New York, NY 10007, USA.
Center for Biomedical Research, Population Council, New York, NY 10605, USA.
Mar Drugs. 2021 Dec 1;19(12):687. doi: 10.3390/md19120687.
Lectins are proteins with a remarkably high affinity and specificity for carbohydrates. Many organisms naturally produce them, including animals, plants, fungi, protists, bacteria, archaea, and viruses. The present report focuses on lectins produced by marine or freshwater organisms, in particular algae and cyanobacteria. We explore their structure, function, classification, and antimicrobial properties. Furthermore, we look at the expression of lectins in heterologous systems and the current research on the preclinical and clinical evaluation of these fascinating molecules. The further development of these molecules might positively impact human health, particularly the prevention or treatment of diseases caused by pathogens such as human immunodeficiency virus, influenza, and severe acute respiratory coronaviruses, among others.
凝集素是一类对碳水化合物具有高度亲和力和特异性的蛋白质。许多生物自然产生凝集素,包括动物、植物、真菌、原生生物、细菌、古菌和病毒。本报告重点介绍了海洋或淡水生物,特别是藻类和蓝细菌产生的凝集素。我们探讨了它们的结构、功能、分类和抗菌特性。此外,我们还研究了凝集素在异源系统中的表达以及这些迷人分子的临床前和临床评估的当前研究。这些分子的进一步发展可能会对人类健康产生积极影响,特别是预防或治疗人类免疫缺陷病毒、流感和严重急性呼吸冠状病毒等病原体引起的疾病。