Zhou Quan, Hotta Kinya, Deng Yaming, Yuan Rui, Quan Shu, Chen Xi
Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an 710127, China.
Genetech Biotechnology Pte Ltd., 8 Temasek Boulevard #34-03, Singapore 038988, Singapore.
Microorganisms. 2021 Dec 10;9(12):2551. doi: 10.3390/microorganisms9122551.
Natural products play an important role in drug development, among which marine natural products are an underexplored resource. This review summarizes recent developments in marine natural product research, with an emphasis on compound discovery and production methods. Traditionally, novel compounds with useful biological activities have been identified through the chromatographic separation of crude extracts. New genome sequencing and bioinformatics technologies have enabled the identification of natural product biosynthetic gene clusters in marine microbes that are difficult to culture. Subsequently, heterologous expression and combinatorial biosynthesis have been used to produce natural products and their analogs. This review examines recent examples of such new strategies and technologies for the development of marine natural products.
天然产物在药物开发中发挥着重要作用，其中海洋天然产物是一种尚未充分探索的资源。本综述总结了海洋天然产物研究的最新进展，重点关注化合物的发现和生产方法。传统上，具有有用生物活性的新型化合物是通过粗提物的色谱分离来鉴定的。新的基因组测序和生物信息学技术使得在难以培养的海洋微生物中鉴定天然产物生物合成基因簇成为可能。随后，异源表达和组合生物合成已被用于生产天然产物及其类似物。本综述考察了海洋天然产物开发中此类新策略和新技术的近期实例。
