Liu Yan, Li Xiaojie, Chen Cai, Leng Aijing, Qu Jialin
Department of Traditional Chinese Medicine, The First Affiliated Hospital of Dalian Medical University, No. 222, Zhongshan Road, Dalian, 116011, China.
Clinical Laboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, No. 222, Zhongshan Road, Dalian, 116011, China.
Chin Med. 2021 Dec 24;16(1):143. doi: 10.1186/s13020-021-00554-8.
Traditional Chinese medicines are an important class of natural products mainly derives from animals, plants and minerals, most of which need to be improved and processed before clinical use due to their own hard texture, impurities or toxicity. As an important part of solid excipients, mineral excipients that contain some metal elements play indispensable and unique roles in the pretreatment process of traditional Chinese medicine. However, deficiency of holistic understanding of the effect of mineral excipients hinders their application and development. This article reviews several mineral excipients including alumen, talci pulvis, soil, soda lime, halloysitum rubrum and cinnabaris systemically. Their processing significance on traditional Chinese medicines were revealed from components, pharmacodynamics and mechanism aspects. Furthermore, prospect and problems including processing technologies, quality standards of mineral excipients and processing mechanism were put forward. This review supply comprehensive information for better and scientific usage of mineral excipients in processing traditional Chinese medicines.
中药是一类重要的天然产物，主要来源于动物、植物和矿物，由于其质地坚硬、含有杂质或具有毒性，大多数中药在临床使用前需要进行炮制加工。矿物辅料作为固体辅料的重要组成部分，其中含有的一些金属元素在中药炮制过程中发挥着不可或缺且独特的作用。然而，对矿物辅料作用的整体认识不足阻碍了其应用与发展。本文系统综述了白矾、滑石粉、泥土、石灰、赤石脂和朱砂等几种矿物辅料，从成分、药效学和作用机制等方面揭示了它们对中药的炮制意义。此外，还提出了包括矿物辅料的炮制工艺、质量标准及炮制机制等方面的展望与问题。本综述为更好、科学地使用矿物辅料炮制中药提供了全面的信息。
