College of Agriculture, Yanbian University, Yanji 133002, P.R. China.
Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences, Changchun 130033, P.R. China.
J Microbiol Biotechnol. 2022 Feb 28;32(2):212-219. doi: 10.4014/jmb.2111.11031.
Recently, the efficacy of probiotics in treatment of neurodegenerative disorders has been reported in animal and clinical studies. Here, we assessed the effects of JA845 in counteracting the symptoms of D-galactose (D-gal)/AlCl-induced Alzheimer's disease (AD) in a mice model through behavioral test, histological assessment and biochemical analysis. Ten weeks of pre-treatment with JA845 prevented cognitive decline, attenuated hippocampal lesion and protected neuronal integrity, which demonstrated the neuroprotective features of JA845 in vivo. We also found that supplementation of JA845 alleviated amyloid-beta deposits and hyperphosphorylated tau in hippocampus of D-gal/AlCl-induced AD model mice. Furthermore, JA845 administration attenuated oxidative stress and decreased serum concentration of inflammatory cytokines by regulating the Nrf2/HO-1 and MyD88/TRAF6/NF-κB pathway. Our results demonstrated for the first time that has the potential to help prevent cognitive decline and might be a novel therapeutic approach for the treatment of neurodegenerative diseases.
最近，动物和临床研究都报道了益生菌在治疗神经退行性疾病方面的疗效。在这里，我们通过行为测试、组织学评估和生化分析，评估了 JA845 在对抗 D-半乳糖（D-gal）/AlCl 诱导的阿尔茨海默病（AD）小鼠模型中症状的作用。10 周的 JA845 预处理可预防认知能力下降，减轻海马损伤并保护神经元完整性，这表明 JA845 在体内具有神经保护作用。我们还发现，JA845 的补充减轻了 D-gal/AlCl 诱导的 AD 模型小鼠海马中的淀粉样β沉积和过度磷酸化的 tau。此外，JA845 通过调节 Nrf2/HO-1 和 MyD88/TRAF6/NF-κB 通路，减轻氧化应激并降低血清中炎症细胞因子的浓度。我们的研究结果首次表明，JA845 具有预防认知能力下降的潜力，可能是治疗神经退行性疾病的一种新的治疗方法。
