Ko Kwang-Pil, Kim Cheong-Sik, Ahn Younjhin, Park Seon-Joo, Kim Yeon-Jeong, Park Jae Kyung, Lim Young-Khi, Yoo Keun-Young, Kim Sung Soo
Department of Preventive Medicine, Gachon University, Incheon, Korea.
Diabetologia. 2015 Apr;58(4):726-35. doi: 10.1007/s00125-014-3463-x. Epub 2014 Dec 23.
AIMS/HYPOTHESIS: To examine the association between soybean products and risk of type 2 diabetes, we measured four isoflavone biological markers--genistein, daidzein, glycitein and equol--in a nested case-control study.
The study population was composed of 693 cases (316 women and 377 men) and 698 matched controls (317 women and 381 men) within the Korean Genome and Epidemiology Study. The concentrations of isoflavone biomarkers were measured using HPLC-MS/MS on plasma samples that were collected at baseline. A stratified analysis was undertaken to examine the association between plasma isoflavone concentrations and risk of type 2 diabetes according to sex and equol production. Logistic regression models were used to compute ORs and 95% CIs adjusted for confounders.
In women, compared with the lowest quartile of plasma concentration of genistein, the highest quartile exhibited a significantly decreased risk of diabetes (OR 0.58, 95% CI 0.35, 0.95). When stratified by equol-producing status in women, the OR for diabetes in the highest vs the lowest quartile of genistein concentration was 0.31 (95% CI 0.16, 0.60) in equol producers, but genistein concentration was not associated with risk of diabetes in equol non-producers (p for interaction = 0.013). In men, isoflavone concentrations were not associated with risk of diabetes, regardless of equol-producing status.
CONCLUSIONS/INTERPRETATION: High plasma concentrations of genistein were associated with a decreased risk of type 2 diabetes in women. This inverse association was prominent in equol-producing participants. These results suggest a beneficial effect of a high intake of soybean products on risk of type 2 diabetes in women.
目的/假设：为研究大豆制品与2型糖尿病风险之间的关联，我们在一项巢式病例对照研究中测量了四种异黄酮生物标志物——染料木黄酮、黄豆苷元、大豆黄素和雌马酚。
研究人群由韩国基因组与流行病学研究中的693例病例（316名女性和377名男性）和698名匹配对照（317名女性和381名男性）组成。使用高效液相色谱-串联质谱法测定基线时采集的血浆样本中异黄酮生物标志物的浓度。根据性别和雌马酚生成情况进行分层分析，以研究血浆异黄酮浓度与2型糖尿病风险之间的关联。使用逻辑回归模型计算校正混杂因素后的比值比（OR）和95%置信区间（CI）。
在女性中，与染料木黄酮血浆浓度最低四分位数相比，最高四分位数的糖尿病风险显著降低（OR 0.58，95% CI 0.35，0.95）。在女性中按雌马酚生成状态分层时，雌马酚生成者中染料木黄酮浓度最高与最低四分位数相比，糖尿病的OR为0.31（95% CI 0.16，0.60），但在非雌马酚生成者中染料木黄酮浓度与糖尿病风险无关（交互作用p = 0.013）。在男性中，无论雌马酚生成状态如何，异黄酮浓度与糖尿病风险均无关联。
结论/解读：血浆中高浓度的染料木黄酮与女性2型糖尿病风险降低有关。这种负相关在雌马酚生成参与者中尤为突出。这些结果表明，高摄入大豆制品对女性2型糖尿病风险具有有益作用。
