Institute of Brain Science, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Vitalon Foods Company Ltd, Taiwan.
IUBMB Life. 2022 Aug;74(8):748-753. doi: 10.1002/iub.2589. Epub 2021 Dec 28.
Alzheimer's disease (AD) is a neurodegenerative disease that impairs multiple memory domains without an effective prevention or treatment approach. Amyloid plaque-induced neuroinflammation exacerbates neurodegeneration and cognitive impairment in AD. To reduce neuroinflammation, we applied prebiotics or synbiotics to modulate the gut-brain axis in the AD mouse model. AD-like deficits were reduced in mice treated with synbiotics, suggesting that dietary modulation of the gut-brain axis is a potential approach to delay AD progression.
阿尔茨海默病（AD）是一种神经退行性疾病，它会损害多种记忆领域，而目前还没有有效的预防或治疗方法。淀粉样斑块引起的神经炎症会加剧 AD 中的神经退行性变和认知障碍。为了减轻神经炎症，我们应用了益生元和合生素来调节 AD 小鼠模型中的肠脑轴。用合生素来治疗的小鼠的 AD 样缺陷减少了，这表明通过饮食来调节肠脑轴可能是延缓 AD 进展的一种方法。
