School of Materials Science and Engineering, Zhengzhou University, 100 Science Road, Zhengzhou, 450001, PR China.
School of Materials Science and Engineering, Zhengzhou University, 100 Science Road, Zhengzhou, 450001, PR China.
J Mech Behav Biomed Mater. 2022 Feb;126:105062. doi: 10.1016/j.jmbbm.2021.105062. Epub 2021 Dec 24.
Bioglass/chitosan-alginate (BCA) composite scaffolds with remarkable performance for bone tissue engineering are successfully prepared by freeze-drying method. The influence of the addition amount of sodium alginate (SA) on the microstructure, porosity, pore size, swelling ratio, degradation ratio, mechanical properties and mineralization ability of BCA composite scaffolds is studied and characterized by various techniques of the scanning electron microscopy, X-ray diffraction, infrared absorption spectrometer and so on. The results show that the BCA composite scaffolds have the three-dimensional interconnected network structure with the high porosity of 82%-87% and a suitable average pore size of 140-200 μm. With the increase of SA addition, the porosity and pore size of BCA gradually reduced and the thickness of pore wall increased. The swelling and degradation ratios decreased gradually with the raising SA and increased with the prolongation of soaking time in PBS. The mechanical strength of BCA was also significantly enhanced, and the mineralization ability of bioglass was effectively deployed with the adding SA of BCA. The improved performance of BCA may be attributed to the formed 3D network structure, activated bioavailability and crosslinking ability between chitosan and SA. It indicates that BCA composite scaffolds have potential applications in bone issues engineering.
采用冷冻干燥法成功制备了具有优异性能的用于骨组织工程的生物玻璃/壳聚糖-海藻酸钠（BCA）复合支架。通过扫描电子显微镜、X 射线衍射、红外吸收光谱仪等多种技术对添加不同量海藻酸钠（SA）对 BCA 复合支架的微观结构、孔隙率、孔径、溶胀率、降解率、力学性能和矿化能力的影响进行了研究和表征。结果表明，BCA 复合支架具有三维互联网络结构，具有 82%-87%的高孔隙率和 140-200μm 的适宜平均孔径。随着 SA 添加量的增加，BCA 的孔隙率和孔径逐渐减小，孔壁厚度增加。溶胀率和降解率随着 SA 的增加而逐渐降低，随着在 PBS 中浸泡时间的延长而增加。BCA 的机械强度也显著增强，并且添加 SA 后有效地提高了生物玻璃的矿化能力。BCA 性能的提高可能归因于形成的 3D 网络结构、壳聚糖和 SA 之间的生物活性和交联能力。这表明 BCA 复合支架在骨组织工程中有潜在的应用。
