Heuer-Jungemann Amelie, Linko Veikko
Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.
Center for Nanoscience, Ludwig-Maximilians University, 80539 Munich, Germany.
ACS Cent Sci. 2021 Dec 22;7(12):1969-1979. doi: 10.1021/acscentsci.1c01272. Epub 2021 Nov 18.
Nucleic acid nanotechnology lays a foundation for the user-friendly design and synthesis of DNA frameworks of any desirable shape with extreme accuracy and addressability. Undoubtedly, such features make these structures ideal modules for positioning and organizing molecules and molecular components into complex assemblies. One of the emerging concepts in the field is to create inorganic and hybrid materials through programmable DNA templates. Here, we discuss the challenges and perspectives of such DNA nanostructure-driven materials science engineering and provide insights into the subject by introducing various DNA-based fabrication techniques including metallization, mineralization, lithography, casting, and hierarchical self-assembly of metal nanoparticles.
核酸纳米技术为以极高的精度和可寻址性对任何所需形状的DNA框架进行用户友好型设计和合成奠定了基础。毫无疑问，这些特性使这些结构成为将分子和分子组件定位并组织成复杂组装体的理想模块。该领域中一个新兴的概念是通过可编程DNA模板创建无机和混合材料。在此，我们讨论这种由DNA纳米结构驱动的材料科学工程所面临的挑战和前景，并通过介绍各种基于DNA的制造技术，包括金属化、矿化、光刻、铸造以及金属纳米颗粒的分级自组装，来深入了解这一主题。
