Center for Health Decision Science, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Research Institute for Humanity and Nature, Japan.
Hum Vaccin Immunother. 2021 Dec 2;17(12):5361-5366. doi: 10.1080/21645515.2021.2013078. Epub 2021 Dec 29.
Measles is highly infectious that leads to a high disease burden among the vulnerable population, especially in developing countries, despite the availability of highly effective measles vaccine. Immune amnesia, the resetting of the immune systems of infected patients, has been observed in developed countries. This paper is the first to use various African countries to evaluate the extent of immune amnesia.
We used two panel datasets from 46 African countries between 1990 and 2018 among children, one is the disease prevalence from Global Burden of Disease, and another is on the measles vaccination coverage from WHO/UNICEF Joint Reporting Form. We used panel regression to estimate the effect of measles prevalence or measles vaccination coverage on other disease prevalence (diarrhea, lower respiratory infection, malaria, meningitis, and tuberculosis).
We found the strong evidence that the increase in the measles prevalence led to an increase in other disease prevalence and mortality. We also found that the increase in the measles vaccination coverage decreased the prevalence of and the mortality due to other diseases.
Measles vaccination can have a large impact on children's health because not only does it reduce the prevalence of measles cases and deaths but also could it potentially reduce the prevalence of and deaths due to other diseases.
麻疹具有高度传染性，尽管有高效的麻疹疫苗，但在发展中国家，这种疾病仍对弱势群体造成了沉重负担。在发达国家，人们已经观察到免疫记忆丧失，即感染患者的免疫系统重置。本文首次利用来自 46 个非洲国家的数据评估了免疫记忆丧失的程度。
我们使用了 1990 年至 2018 年期间来自全球疾病负担和世界卫生组织/联合国儿童基金会联合报告表的两个面板数据集，一个是疾病流行率，另一个是麻疹疫苗接种覆盖率，用于评估麻疹流行率或麻疹疫苗接种覆盖率对其他疾病流行率（腹泻、下呼吸道感染、疟疾、脑膜炎和结核病）的影响。我们使用面板回归来估计麻疹流行率或麻疹疫苗接种覆盖率对其他疾病流行率（腹泻、下呼吸道感染、疟疾、脑膜炎和结核病）的影响。
我们发现有力的证据表明，麻疹流行率的增加导致其他疾病的流行率和死亡率增加。我们还发现，麻疹疫苗接种覆盖率的增加降低了其他疾病的流行率和死亡率。
麻疹疫苗接种可以对儿童健康产生重大影响，因为它不仅降低了麻疹病例和死亡的流行率，而且可能降低了其他疾病的流行率和死亡率。
