Evaluation on the generalization of a learned convolutional neural network for MRI reconstruction.

Recently, deep learning approaches with various network architectures have drawn significant attention from the magnetic resonance imaging (MRI) community because of their great potential for image reconstruction from undersampled k-space data in fast MRI. However, the robustness of a trained network when applied to test data deviated from training data is still an important open question. In this work, we focus on quantitatively evaluating the influence of image contrast, human anatomy, sampling pattern, undersampling factor, and noise level on the generalization of a trained network composed by a cascade of several CNNs and a data consistency layer, called a deep cascade of convolutional neural network (DC-CNN). The DC-CNN is trained from datasets with different image contrast, human anatomy, sampling pattern, undersampling factor, and noise level, and then applied to test datasets consistent or inconsistent with the training datasets to assess the generalizability of the learned DC-CNN network. The results of our experiments show that reconstruction quality from the DC-CNN network is highly sensitive to sampling pattern, undersampling factor, and noise level, which are closely related to signal-to-noise ratio (SNR), and is relatively less sensitive to the image contrast. We also show that a deviation of human anatomy between training and test data leads to a substantial reduction of image quality for the brain dataset, whereas comparable performance for the chest and knee dataset having fewer anatomy details than brain images. This work further provides some empirical understanding of the generalizability of trained networks when there are deviations between training and test data. It also demonstrates the potential of transfer learning for image reconstruction from datasets different from those used in training the network.