Leong Xin-Fang, Choy Ker Woon, Alias Aspalilah
Department of Craniofacial Diagnostics and Biosciences, Faculty of Dentistry, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Department of Anatomy, Faculty of Medicine, Universiti Teknologi MARA, Selangor, Malaysia.
Front Pharmacol. 2021 Dec 15;12:758929. doi: 10.3389/fphar.2021.758929. eCollection 2021.
Atherosclerosis poses serious health problems and increases the risk of various cardiovascular diseases, including myocardial infarction, heart failure, ischemic stroke, and peripheral arterial disease. Atherosclerosis patients require long-term medications to prevent complications, some of which are costly and may result in unwanted adverse reactions. Natural products have emerged as potential sources of bioactive compounds that provide health benefits in cardiovascular diseases. Increased inflammation and vascular remodeling have been associated with atherosclerosis pathogenesis. The molecules involved in signaling pathways are considered valuable targets for new treatment approaches. Therefore, this review aimed to summarize the available evidence of the anti-inflammatory effects of thymoquinone, the major active compound isolated from L, inflammatory signaling pathways in atherosclerosis. Specifically, nuclear factor-κB and mitogen-activated protein kinase signaling pathways were considered. Furthermore, the potential toxic effects elicited by thymoquinone were addressed. These findings suggest a potential role of thymoquinone in managing atherosclerosis, and further studies are required to ascertain its effectiveness and safety profile.
动脉粥样硬化会引发严重的健康问题，并增加患各种心血管疾病的风险，包括心肌梗死、心力衰竭、缺血性中风和外周动脉疾病。动脉粥样硬化患者需要长期服药以预防并发症，其中一些药物价格昂贵，且可能会导致不良副作用。天然产物已成为生物活性化合物的潜在来源，这些化合物对心血管疾病具有有益健康的作用。炎症增加和血管重塑与动脉粥样硬化的发病机制有关。信号通路中涉及的分子被认为是新治疗方法的有价值靶点。因此，本综述旨在总结从黑种草籽中分离出的主要活性化合物百里醌在动脉粥样硬化中的抗炎作用的现有证据，具体考虑了核因子-κB和丝裂原活化蛋白激酶信号通路。此外，还讨论了百里醌引发的潜在毒性作用。这些发现表明百里醌在管理动脉粥样硬化方面具有潜在作用，需要进一步研究以确定其有效性和安全性。
