降钙素基因相关肽和血管活性肠肽在人体体内及体外作为血管舒张剂的作用。
The actions of calcitonin gene related peptide and vasoactive intestinal peptide as vasodilators in man in vivo and in vitro.
作者信息
Thom S M, Hughes A D, Goldberg P, Martin G, Schachter M, Sever P S
出版信息
Br J Clin Pharmacol. 1987 Aug;24(2):139-44. doi: 10.1111/j.1365-2125.1987.tb03154.x.
Abstract
1 The two peptides calcitonin gene related peptide (CGRP) and vasoactive intestinal peptide (VIP) produced marked dilatation of the forearm vascular bed when infused via the brachial artery. 2 CGRP relaxed preconstricted segments of human radial, coronary, gastric and cerebral arteries in an endothelium dependent manner. 3 VIP relaxed human gastric and transverse cervical arteries in an endothelium dependent manner, but relaxation of the human pulmonary artery was not dependent on endothelium. 4 The characteristics of the endothelium dependent relaxation of these medium-sized muscular arteries indicated involvement of the endothelium derived relaxing factor in vitro. 5 Caution is expressed in drawing comparisons between the mechanisms involved in the in vivo and in vitro vascular responses.
摘要
- 降钙素基因相关肽（CGRP）和血管活性肠肽（VIP）这两种肽经肱动脉注入时，可使前臂血管床显著扩张。2. CGRP以依赖内皮的方式舒张人桡动脉、冠状动脉、胃动脉和脑动脉的预收缩节段。3. VIP以依赖内皮的方式舒张人胃动脉和颈横动脉，但人肺动脉的舒张不依赖内皮。4. 这些中膜肌性动脉的内皮依赖性舒张特征表明，体外存在内皮源性舒张因子的参与。5. 在对体内和体外血管反应所涉及的机制进行比较时需谨慎。
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